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Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2014-03-18 to 2014-06-11
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP Guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- yes
- Remarks:
- The water solubility test was not shaken at 30°C and equilibrated at 20°C, but shaken directly at 20°C. The deviation had no impact on the study.
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- yes
- Remarks:
- see previous comment
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Water solubility:
- 0.036 g/L
- Temp.:
- 20 °C
- pH:
- 6.6
- Remarks on result:
- other: Total organic carbon based on nominal loading rate of 0.1 g/L
- Water solubility:
- 0.002 g/L
- Temp.:
- 20 °C
- pH:
- 6.6
- Remarks on result:
- other: boron based on nominal loading rate of 0.1 g/L
- Details on results:
- Preliminary test
The preliminary estimate of water solubility was 4.25E-02 g/L at 20.0°C by TOC.
Definitive test
The correlations (r2) of the TC and IC calibration plots were all at least 0.9999.
As it was known that the test item was hydrolytically unstable it was decided to perform the test with reduced shaking periods and directly at 20°C as an elevated temperature of 30°C would hydrolyse the test item at a more rapid rate. The samples were prepared at a nominal loading rate of 100 mg/L to tie in with the upper concentration limit of ecotoxicological testing.
Due to the instability of the test item, a substance specific analytical method was not available. Therefore, the samples were analysed for total organic carbon and boron by ICP-MS. The boron analysis identified the concentration of the degradation product, boric acid, was in solution.
Based on the representative structure of the test item, boron accounts for 2.24% by mass. As the mean boron concentration was 2.43 mg/L, this would equate to 108 mg/L of the test item. The loading rates of the 3 samples ranged from 111 to 113 mg/L, so it can be clearly seen that all or nearly all the boron had dissolved when taking into account the test item might not be 100% of the representative structure and analytical inaccuracies.
The organic part of the test item, which after decomposition of the test item was 2-propyl-1-heptanol, had a mean concentration of 35.6 mg/L With this representing 97.76% of the test item by mass, it only equates to 36.4 mg/L of test item which is significantly lower than the sample loading rates. This shows that not all the organic part of the test item had dissolved in the water. Considering this with the boron results, the test item appeared to have decomposed because the results (corrected to test item concentration) would have been the same if decomposition had not occurred.
As the results were consistent for all samples and taking the above conclusion into account, the test item must have essentially all degraded within 1 hour at 20°C.
The preliminary test was performed at a higher nominal loading rate of 1000 mg/L, ten times higher that the definitive test. Even so, with a total organic carbon result of 42.5 mg/L it indicated that loading rate would have no significant effect (assuming enough organic components were available to reach saturation) and suggests saturation had been reached. Whereas, the boron concentration would be expected to mirror the loading rate concentration as the test item would hydrolyse and boric acid is highly water soluble.
An estimation of water solubility using WSKOW v 1.42 (US EPA) gave a low solubility of 2.8E-7 mg/L. - Conclusions:
- Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L) The substance hydrolyses in water.
The water solubility of the test item at 20.0°C was determined to be 3.56E-02 g/L of the total organic cabon and 2.43E-03 g/L boron based on a nominal loading rate of 0.1 g/L. The water solubility of the test item could not be determined directly due to it being hydrolytically unstable in water. - Executive summary:
Guideline
EC Method A6 of Commission Directive 92/69/EEC and OECD Guideline No. 105; flask method.
Result
The water solubility of the test item at 20.0 °C was determined to be 3.56E-02 g/L of the total organic cabon and 2.43E-03 g/L boron based on a nominal loading rate of 0.1 g/L. The water solubility of the test item could not be determined directly due to it being hydrolytically unstable in water.
Reference
See attached document.
Description of key information
The water solubility of the test item at 20.0°C was determined to be 3.56E-02 g/L of the total organic carbon and 2.43E-03 g/L boron based on a nominal loading rate of 0.1 g/L. The water solubility of the test item could not be determined directly due to it being hydrolytically unstable in water.
Key value for chemical safety assessment
- Water solubility:
- 0.036 g/L
- at the temperature of:
- 20 °C
Additional information
The water solubility of the test item at 20.0°C was determined to be 3.56E-02 g/L of the total organic cabon and 2.43E-03 g/L boron based on a nominal loading rate of 0.1 g/L. The water solubility of the test item could not be determined directly due to it being hydrolytically unstable in water.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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