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Diss Factsheets
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EC number: 210-695-4 | CAS number: 621-62-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1990
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- For the assessment of ethane, 2-chloro-1,1-diethoxy (chloroacetaldehyde-diethylacetal) a read-across approach to the structural analogue ethane, 2-chloro-1,1-dimethoxy (chloroacetaldehyde-dimethylacetal) has been considered appropriate as both substances have similar physical-chemical properties. The dimethylacetal can be considered as a worst-case-approach as it has a lower molecular weight compared with the diethylacetal. The dimethylacetal has a lower pH in water, a higher water solubility, a higher vapour pressure, boiling point and flammability. Stability and hydrolysis are also comparable with ethane, 2-chloro-1,1-diethoxy resp. ethane, 2-chloro-1,1-dimethoxy reacting with acids releasing chloroacetaldehyde and ethanol resp. methanol. Here also the release of methanol can be - compared to the release of ethanol - considered as a worst-case approach.
Therefore the read-across from the diethoxy-compound to the dimethoxy-compound is considered appropriate.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Reference
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1990
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD Guideline Study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- Californian
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Schweizer Hof Untergröningen, Dr. Zimmermann
- Housing: individually in suspended stainless steel cages (2450 cm²)
- Diet: Raiffeisen Alleinfuttermittel 52/P for rabbits, once daily ca 180g
- Water: ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-22
- Humidity (%): 45-70
- Photoperiod (hrs dark / hrs light): 12/12 - Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Controls:
- yes
- Amount / concentration applied:
- TEST MATERIAL: Amount applied: 0.5mL of the substance
VEHICLE: water - Duration of treatment / exposure:
- 4h
- Observation period:
- 14d
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: back
- coverage: 6 cm²
- Type of wrap if used: no data, but warp was used
REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes, carefully
- Time after start of exposure: 4h
SCORING SYSTEM: mortality, toxic symptoms, general state of health, behaviour, body weight, skin results - Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24h
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 14d
- Score:
- 1
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: day 1-day 6
- Score:
- 1
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: day 7
- Score:
- 0
- Reversibility:
- fully reversible
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under described test conditions following skin changes resulted from the test of chloroacetaldehyde dimethylacetal in albino-rabbits:
Erythema score: 1
Edema score: 0
Up from day 7 after substance application no changes were visible. Acute systemic toxic symptoms were not recognized.
The animals showed body weight gain during the observation period. - Executive summary:
Chloroacetaldehyde dimethylacetal was tested according to OECD Guideline 404 in 3 Albino Rabbits (Amount per animal: 0.5ml).
Under the test conditions skin changes resulted, assessed with max. 1 point erythema score. There was no edema score observed. Up from day 7 after substance application no changes were observed. Acute systemic toxic symptoms were not recognized.
The animals showed body weight gain during the observation period.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Ethane, 2-Chloro-1,1-Dimethoxy-
- IUPAC Name:
- Ethane, 2-Chloro-1,1-Dimethoxy-
- Reference substance name:
- 97-97-02
- IUPAC Name:
- 97-97-02
- Reference substance name:
- 2-chloro-1,1-dimethoxyethane
- EC Number:
- 202-624-0
- EC Name:
- 2-chloro-1,1-dimethoxyethane
- Cas Number:
- 97-97-2
- Molecular formula:
- C4H9ClO2
- IUPAC Name:
- 2-chloro-1,1-dimethoxyethane
- Test material form:
- other: colourless liquid
- Details on test material:
- - Name of test material (as cited in study report): Chloroacetaldehyde dimethylacetal
- Physical state: colourless liquid
- Storage condition of test material: room temperature
- Container: brown glass bottle x2
Constituent 1
Constituent 2
Constituent 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- ca. 1
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 7 d
- Score:
- ca. 0
- Reversibility:
- fully reversible
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.