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EC number: 210-695-4 | CAS number: 621-62-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1991
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- For the assessment of ethane, 2-chloro-1,1-diethoxy (chloroacetaldehyde-diethylacetal) a read-across approach to the structural analogue ethane, 2-chloro-1,1-dimethoxy (chloroacetaldehyde-dimethylacetal) has been considered appropriate as both substances have similar physical-chemical properties. The dimethylacetal can be considered as a worst-case-approach as it has a lower molecular weight compared with the diethylacetal. The dimethylacetal has a lower pH in water, a higher water solubility, a higher vapour pressure, boiling point and flammability. Stability and hydrolysis are also comparable with ethane, 2-chloro-1,1-diethoxy resp. ethane, 2-chloro-1,1-dimethoxy reacting with acids releasing chloroacetaldehyde and ethanol resp. methanol. Here also the release of methanol can be - compared to the release of ethanol - considered as a worst-case approach.
Therefore the read-across from the diethoxy-compound to the dimethoxy-compound is considered appropriate.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Reference
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1991
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD Guideline Study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- GLP compliance:
- yes
- Analytical monitoring:
- no
- Vehicle:
- no
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
- Common name: zebra danio
- Source: West Aquarium, D-Bad Lauterberg
- Length at study initiation: 2-3cm
- Weight at study initiation: 0.35g in average
- Feeding during test: no
ACCLIMATION
- Acclimation period: 7d in test water befor study initiation
- Acclimation conditions (same as test or not): yes
- Type and amount of food: flakes (Tetra Min Hauptfutter)
- Feeding frequency: 3 times/week, last feeding 24h before study initiation
- Health during acclimation (any mortality observed):
QUARANTINE
- Duration: 12d in quarantine
- Health/mortality: no external visible illnesses/0.25% - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96
- Remarks on exposure duration:
- h
- Hardness:
- 2.83 - 3.14 mmol/L
- Test temperature:
- 21 +/- 1°C
- pH:
- 7.39-7.49
- Nominal and measured concentrations:
- nominal: 0, 25, 50, 100, 200, 400 mg/L
measured: 0, 26.31/24.76, 47.78/48.84, 99.46/92.11, 205.48/204.58, 405.81/396.37 mg/L - Details on test conditions:
- TEST SYSTEM
- Material, size, headspace, fill volume: 10L
- Aeration: no
- Renewal rate of test solution (frequency/flow rate): every 24h
- No. of organisms per vessel: 10
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: tab water
Dilution water:
CaCl2: 2 mmol/L, MgSO4: 0.5 mmol/L, NaHCO3: 0.75 mmol/L, KCl: 0.075 mmol/L
The sum of the Calcium- and Magnesium ions in the dilution water is 2.5 mmol/L. The relation of Ca : Mg ions 4 : 1 and Na : K ions 10 : 1. The acid capacity of the solution is 0.8 mmol/L. The water will be aerated until oxygen saturation; afterwards the stock solutions will be mixed with 500mL dilution water.
Stock solutions:
(1): 0.5 g/L Chloroacetaldehyde dimethylacetal, (2): 1 g/L Chloroacetaldehyde dimethylacetal, (3): 2 g/L Chloroacetaldehyde dimethylacetal, (4) 4 g/L Chloroacetaldehyde dimethylacetal, (5): 8 g/L Chloroacetaldehyde dimethylacetal.
stock solution : dilution water is 1 : 20
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16 light/8 dark
- Light intensity: 2000 lux - Reference substance (positive control):
- no
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 50 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- 50 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC100
- Effect conc.:
- 200 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Details on results:
- - Behavioural abnormalities: balance disorders in 1 fish (24h) and 2 fish (48h)
- Observations on body length and weight: normal: 2,8 cm in average and 0.35g in average
- Mortality of control: no
- Other adverse effects control: no - Validity criteria fulfilled:
- yes
- Conclusions:
- Chloroacetaldehyde dimethylacetal was tested according to OECD Guideline 203 tested in zebra danio (Brachydanio rerio (new name: Danio rerio)). 2 out of 6 died, so the mortality was 1/3 at a concentration of 100 mg/l.
- Executive summary:
Chloroacetaldehyde dimethylacetal was tested according to OECD Guideline 203 tested in zebra danio (Brachydanio rerio (new name: Danio rerio)). The LD50 is > 100 mg/l.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Ethane, 2-Chloro-1,1-Dimethoxy-
- IUPAC Name:
- Ethane, 2-Chloro-1,1-Dimethoxy-
- Reference substance name:
- 97-97-02
- IUPAC Name:
- 97-97-02
- Reference substance name:
- 2-chloro-1,1-dimethoxyethane
- EC Number:
- 202-624-0
- EC Name:
- 2-chloro-1,1-dimethoxyethane
- Cas Number:
- 97-97-2
- Molecular formula:
- C4H9ClO2
- IUPAC Name:
- 2-chloro-1,1-dimethoxyethane
- Test material form:
- other: colourless liquid
- Details on test material:
- - Name of test material (as cited in study report): Chloroacetaldehyde dimethylacetal
- Physical state: colourless liquid
- Storage condition of test material: room temperature
- Container: brown glass bottle x2
Constituent 1
Constituent 2
Constituent 3
Results and discussion
Effect concentrations
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- ca. 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.