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Diss Factsheets
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EC number: 212-028-2 | CAS number: 751-83-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- no data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data are given; pre-GLP study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- 2 animals; treatment time: 1, 5, 15 min, 20 h; observation after 24 hours and 8 days
- Principles of method if other than guideline:
- Before OECD TG 404 was established in 1984, skin irritation was tested using an internal method (BASF Test).
- GLP compliance:
- no
- Remarks:
- pre-GLP study
Test material
- Reference substance name:
- [3-methyl-5-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4-pentadienyl]triphenylphosphonium sulphate
- EC Number:
- 212-028-2
- EC Name:
- [3-methyl-5-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4-pentadienyl]triphenylphosphonium sulphate
- Cas Number:
- 751-83-7
- Molecular formula:
- C33H38P.HO4S
- IUPAC Name:
- mono[3-methyl-5-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4-pentadienyl]triphenylphosphonium hydrogensulphate
- Details on test material:
- - Name of test material (as cited in study report): C15-Salz, i.e. beta-ionylidene ethyl-triphenylphosphonium hydrogensulphate, solid
- Analytical purity: no data
No further data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- no further data
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Controls:
- other: untreated skin of the same animals
- Amount / concentration applied:
- TEST MATERIAL
- Concentration (if solution): 50% aqueous suspension - Duration of treatment / exposure:
- 1 min, 5 min, 15 min (short-term test)
20 h (long-term test) - Observation period:
- 8 days
- Number of animals:
- 2 animals (short-term test)
2 animals (long-term test) - Details on study design:
- TEST SITE
- Area of exposure: back and ear
An application site of 2.5 cm x 2.5 cm was covered with the test substance. In addition, skin tissue from the ear was tested. These results from the ear were not taken into account for evaluation as they do not represent testing of the dorsal/lateral flank of the back as required by current Testing Guidelines.
REMOVAL OF TEST SUBSTANCE
- Washing: yes
- Time after start of exposure: at the end of the respective exposure times
At the end of the respective application time (i.e. 1 min, 5 min, 15 min , 20 h), the sites were wiped with water containing a mild detergent.
SCORING SYSTEM: BASF scoring system, convertible to Draize score
The animals were observed for 7-8 days and skin changes were recorded on working days.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Remarks:
- 20-hour exposure
- Basis:
- mean
- Remarks:
- of n=2
- Time point:
- other: 24 hours - 8 days
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: necrosis observed; skin not evaluable at 8 d
- Irritation parameter:
- edema score
- Remarks:
- 20-hour exposure
- Basis:
- mean
- Remarks:
- of n=2
- Time point:
- other: 24 hours - 8 days
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: necrosis observed; skin not evaluable at 8 d
- Irritation parameter:
- erythema score
- Remarks:
- exposure for 1, 5, 15 min
- Basis:
- mean
- Remarks:
- of n=2
- Time point:
- other: 24 hours - 8 days
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: necrosis observed
- Irritation parameter:
- edema score
- Remarks:
- exposure for 1, 5, 15 min
- Basis:
- mean
- Remarks:
- of n=2
- Time point:
- other: 24 hours - 8 days
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: necrosis or desquamation observed
- Irritant / corrosive response data:
- Animals exhibited erythema grade 1-2 and signs of necrosis already 24 h after removal of the patches. These lesions were not reversible within 8 days.
Partially, the scores for erythema and edema at the treated skin sites could not be evaluated because of this necrosis. Therefore, an irritation index was not calculated; the skin irritation was classified based on the necrosis findings.
For details, see table below.
Any other information on results incl. tables
Table: skin findings (erythema and edema scores converted to Draize system); mean scores (mean of n = 2)
Application site |
Exposure time |
Findings after |
|||||
24 hours |
8 days |
||||||
erythema |
edema |
other findings, remarks |
erythema |
edema |
other findings, remarks |
||
back |
1 min |
1 |
1 |
spotted erythema |
0 |
0 |
desquamation |
5 min |
1 |
1 |
|
* |
* |
focal necrosis |
|
15 min |
* 1 ** |
* 2 ** |
superficial necrosis |
* |
* |
focal necrosis, margins sclerotic |
|
back |
20 h |
* 1 ** |
* 1 ** |
superficial necrosis |
* |
* |
focal necrosis margins sclerotic |
ear |
20 h |
1 |
1 |
discharge |
* |
* |
superficial necrosis |
*: application site: not evaluable, due to necrosis
**: findings at the margins of necrosis
Applicant's summary and conclusion
- Interpretation of results:
- Category 1B (corrosive) based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- The test substance was classified as corrosive (Cat. 1), based on necrosis observed after exposure for 5 minutes.
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