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Diss Factsheets
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EC number: 212-028-2 | CAS number: 751-83-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
ORAL
LD50, rat, combined = 1735 mg/kg bw (95% C.I. 1248 - 2412)
DERMAL
No data are available.
INHALATION
No mortality was observed when 12 rats were exposed by inhalation to an atmosphere that had been saturated at 20°C with the volatile parts of C15-Salz (purity not given) for up to 8 hours.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 1 735 mg/kg bw
Additional information
- Oral LD50 Combined = 1735 mg/kg bw (95% C.I. 1248 - 2412)
ORAL
In an acute oral toxicity study (BASF, 1975), groups of Sprague-Dawley rats (5/sex) were given a single oral dose of C15-Salz (purity not given) in olive oil at doses of 1000, 1470, 2150, 4640, or 6810 mg/kg bw and observed for 14 days.
C15-Salz is of MODERATE Toxicity based on the LD50 in male and female rats.
Clinical signs of toxicity included prone position, apathy, diarrhea, exsiccosis, spastic gait, emaciation, and reddish encrustations around the snout and nose. Pathological examination revealed dilatation of the heart and/or stomach, congestive hyperemia, liquid content of the stomach, diarrhetic content of the intestine, caustic eschar, and intraabdominal adhesions.
DERMAL
No data are available.
INHALATION
In an Inhalation Risk Test (BASF, 1975), totally 12 rats were exposed by inhalation route to an atmosphere that had been saturated at 20°C with the volatile parts of C15-Salz (purity not given) for up to 8 hours. Animals then were observed for 14 days. No deaths occurred; no clinical symptoms and no pathological findings were observed. C15-Salz is classified as being of LOW Toxicity based on lack of any adverse observations under the conditions of this test.
Justification for classification or non-classification
Based on the oral LD50 in rats, C15-Salz has to be classified as “harmful if swallowed” according to the Directive 67/548/EC. According to the GHS criteria, C15 -Salz has to be classified as follows: Acute Oral Toxicity Cat. 4.
There is no need to classify C15-Salz for acute inhalation toxicity according to the Directive 67/548/EC or GHS criteria.
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