Registration Dossier
Registration Dossier
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EC number: 500-109-8 | CAS number: 43011-20-7
Endpoint summary
Administrative data
Description of key information
Workers may potentially be exposed to cyclic acid anhydrides, with associated adverse health effects.
Additional information
Workers may be exposed to cyclic acid anhydrides including trimellitic anhydride and phthallic anhydride. Studies in human workers and volunteers provide important information about the pharmacokinetics of cyclic acid anhydrides, measurement of urinary metabolites and measurement of serum immunoglobulins. Irritation symptoms include itching, lacrimation, sneezing, rhinorrhoea, cough, and dyspnoea, which begin immediately following exposure to high concentrations of dusts or vapours. The most common allergic diseases are rhinoconjunctivitis and asthma
The substance is a member of the Selected Cyclic Acid Anhydrides category. This is a subgroup of a larger category, the Cyclic Acid Anhydrides, established by the World Health Organization (WHO) and other expert scientific groups (WHO, 2009). The conclusion of a review of human health effects of exposure to cyclic acid anhydrides is that sensitisation and work-related respiratory and dermal irritation represent the critical risks. Data for several human health endpoints is obtained from category members.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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