Registration Dossier
Registration Dossier
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EC number: 500-109-8 | CAS number: 43011-20-7
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
The key study was an activated sludge respiration inhibition test, which measured the inhibitory effects of a read-across substance (5-Isobenzofurancarboxylic acid, 1,3-dihydro-1,3-dioxo-, polymer with 1,2-propanediol; also known as ZAN 573) on activated sludge micro-organisms from a domestic waste water treatment plant, on the basis of read-across based on a grouping of substances (category approach).
Key value for chemical safety assessment
- EC50 for microorganisms:
- 598.75 mg/L
Additional information
In the key study, a read-across substance (5-Isobenzofurancarboxylic acid, 1,3-dihydro-1,3-dioxo-, polymer with 1,2-propanediol; also known as ZAN 573) was shown to inhibit the respiration of activated sludge micro-organisms, with a calculated 3-h EC50 of 598.75 mg/L (nominal). In a supporting study, a second read-across substance (trimellitic anhydride) was shown to inhibit the respiration of activated sludge micro-organisms, with a 3-h EC50 estimated to fall in the range of 100 mg/L to 500 mg/L (nominal).
A category approach is used for the assessment of several endpoints. The hypothesis for the category of cyclic acid anhydrides is the similar chemical behaviour and analogous breakdown products in environmental and biological systems. The common functional group is a 1,3-dioxo-1,3-dihydro-2-furan ring (i.e., a cyclic acid anhydride) directly attached to an aromatic ring. The cyclic anhydride moiety is quickly hydrolysed to form a dioic acid. The cyclic acid anhydride moiety and its dioic acid derivatives are the principal loci of toxicity, rather than the remainder of the molecule. Within the category, oligomeric forms of the cyclic acid anhydrides are less likely to be absorbed across biological membranes than the simple, monomeric forms, so that this read-across represents the worst case scenario. For each endpoint study based upon read-across, the category approach is substantiated by an evaluation provided in the Chemical Category Report Format (CCRF) attached to the endpoint study summary file. The CCRF allows the read-across information to fulfil the information requirements of the REACH Annexes VII-X, to be the basis for classification and labelling decisions, and for risk assessment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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