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EC number: 248-792-9 | CAS number: 28043-10-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
EC50 (invertebrates) = 23 mg/L (C.I. 19 - 29 mg/L), 48hour-freshwater, OECD TG 202, Wil Research B.V. 2015
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 23 mg/L
Additional information
The acute toxicity to Daphnia magna was carried out according to OECD 202 Daphnia sp., Acute Immobilisation Test and EU Method C.2 guidelines. A limit test was combined with a range-finding test with air-tight closed-vessels without headspace. Twenty Daphnia magna per test group (4 replicates, 5 daphnia per replicate vessel) were exposed to untreated control medium and to a concentration of 1.0, 10.0 and 100% of a 100 mg/L saturated solution in the limit test. No immobilisation was seen at 1.0 or 10% loading rates whereas 100% immobilisation at 100% saturated was observed. A final test was performed based on the results of a finding test. Twenty daphnids per group (5 per replicate, quadruplicate) were exposed to an untreated control and to 5.6, 11.3, 22.5, 45 and 90 mg/L in vessels closed airtight without a headspace. The total exposure period was 48 hours and samples for analytical confirmation of exposure concentrations were taken at the start and at the end of the test. Analysis of the samples taken during the final test showed that measured concentrations were in agreement with nominal throughout the exposure period (i.e. 84-99% of nominal). Therefore, endpoints were based on nominal concentrations. The responses recorded in this test allowed for reliable determination of an EC50, with 0, 5, 50, 90 and 100% immobilisation at 5.6, 11.3, 22.5, 45 and 90 mg/l, respectively. No significant effects on the mobility of daphnia magna were observed at 48 hours up to and including 22.5 mg/L (nominal), while an average of 90% immobile daphnia were observed at 45 mg/L (nominal). There was no significant variation in the results of the combined limit/range-finding test and there were no significant responses at lower concentrations, and test item concentrations were satisfactorily maintained during the course of the study. The study met the acceptability criteria. The 48h-EC50 was 23 mg/L (C.I. 19 and 29 mg/L) based on analytically confirmed nominal concentrations.
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