Registration Dossier
Registration Dossier
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EC number: 619-057-3 | CAS number: 94667-33-1
Endpoint summary
Administrative data
Description of key information
Inherent Biodegradability:
In two simulation tests following OECD Guideline 308 and 314B the fate of the parent molecule have been researched and assessed. Both studies are valid guideline studies with acceptable results and conducted under GLP.
1) In a key study following OECD 314B TG the DT50 of the parent molecule has been determined to be 4.7 hrs and the 50% CO2 production occured at approximately 62 hrs. The overall mineralisation was determined to be 85.98% at the termination of the study on day28. For the biotic treatment, the level of activity associated with the solids was present at 2.29% at the 1-minute sampling interval, increased to 9.67% at the 48 hour interval and declined to 5.79% of initial activity at the termination of the test on day 28. For the abiotic treatment, the level of activity associated with the solids was present at 2.82% at the1-minute sampling interval and increased to 5.19% on day 28.
2) Another key study following OECD 308 TG the test item was assessed using two different water/sediment systems (1WS Pfalz and 2WS Weißach). The study was performed with [N-methyl-14C]Bardap 26 over a period of 100 days. In the test system 1WS the DT50 has been assessed in the water phase with 4.43 d, in the sediment extract with 25.9 d and in the test system 2WS with 1.17 d in the waterphase and 25.3 d in the sediment extract. Recovery rates were between 89.6 and 98.5 % in 1WS resp. 85.1 and 103.9 % in 2WS.
3) In a supporting study, the behaviour of didecyldimethylpoly (oxyethyl) ammonium Propionate was investigated according to OECD Guideline 302B (Zahn-Wellens Test). Activated sludge suspended in a standard mineral salts medium was dosed with Didecyldimethylpoly (oxyethyl) ammonium propionate at 303 mg C-equivalent/L. It should be noted that this concentration considerably exceeds the 3 -hour EC50 for the inhibition of respiration of activated sludge microorganisms and toxicity may have influenced the outcome of the study. Based on the measured DOC concentrations in samples taken after 3h and on days 1, 7, 10, 15, 20 and 28, the % elimination and % biodegradation was calculated after correction for the corresponding blank values.
53% elimination was observed after 3h, indicating a high degree of adsorption. Elimination of didecyldimethylpoly(oxyethyl)ammonium propionate reached 80% after 28 days, representing the combined effects of physico-chemical elimination and biodegradation processes (23% and 57%, respectively). Didecyldimethylpoly(oxyethyl)ammonium propionate removal between the untreated influent and the treated effluent due to the combined effects of abiotic and biological processes was expected to exceed 50% in industrial waste water treatment works.
Ready Biodegradability:
1) The key study was carried out in accordance with OECD Guideline 301B. The ready biodegradability of14C-N,N-didecyl–N-methyl-poly(oxyethyl)ammonium propionate, dosed at 0.2 mg/L, was determined in a ready biodegradability study conducted according to OECD Guideline 301B. The mean cumulative14CO2production was equivalent to 10% after 4 days and progressed rapidly until Day 8. The rate of biodegradation then slowed. 34% biodegradation had occurred by the end of the study, but was less than the 60% required to qualify for classification as readily biodegradable. Under the strict terms and conditions of the OECD Test Guidelines for ready biodegradability N,N-didecyl–N-methyl-poly(oxyethyl)ammonium propionate cannot be termed readily biodegradable.
2) A supporting study was carried out according to the same procedure (OECD Guideline 301B, CO2 Evolution Test), with non radio-labelled test substance dosed at a concentration of 5 mg C-equivalent/L. Didecyldimethylpoly(oxyethyl) ammonium propionate showed 0% degradation at the end of the incubation, confirming the indication of the key study, i.e. that the test substance is not readily biodegradable. There was no evidence of interference due microbial inhibition in the toxicity control included in the study design (the test substance caused no significant suppression of the degradation of the reference substance) and a subsequent (non-standard) toxicity check showed no evidence of microbicidal activity based on total viable counts of the inoculum after exposure to the same concentration of didecyldimethylpoly(oxyethyl) ammonium propionate under incubation conditions identical to those of the biodegradability assessment.
Biodegradation in soil:
[N-methyl-14C]Bardap 26 degraded under aerobic laboratory conditions, with a typical half-live of 14.6, 10.8, 16.2 and 28.2 days in soil extracts for the soils Lufa 2.1, Lufa 2.2, Lufa 2.3 and Lufa 2.4, respectively.
Metabolite M1a reached up to 29.4% and 12.7% AR in the soils Lufa 2.1 and Lufa 2.2, respectively. Metabolites H6 and H10 were observed at higher than 5% AR but less than 10% AR during the study.
H6 was identified but it was not possible to identify H10.
Up to 12 minor transformation products occurred during the incubation period
Additional information
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