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EC number: 234-933-1 | CAS number: 12042-91-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1975
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Information on substance identity is not based on CAS 12042-91-0. Composition is not available. NON - Guideline study. Non- GLP. Statement from company owner is received on substance identity and composition mentioned in study report. Based on this the reliability turned into 2.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- See overall remarks
- Principles of method if other than guideline:
- Not relevant
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Test material form:
- solid
- Details on test material:
- - Name of test material (as cited in study report): Locron P
- Physical state: Solid
- Molecular formula (if other than submission substance): Al2(OH)5Cl.2-3H2O
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Remarks:
- SPF-Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Own breed
- Weight at study initiation: 102 g (80 - 137 g)
- Fasting period before study: 16 hours
- Housing: Plastic cages filled with sawdust
- Diet (e.g. ad libitum): Altromin 1324 (of the company Altrogge in Lage/Lippe), ad libitum
- Water (e.g. ad libitum): Tap water, ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: sesame oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: test concentrations: 25% - Doses:
- 6300, 8000, 10000 and 15000 mg/kg body weight
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: weighing: once a week
- Necropsy of survivors performed: yes
- Other examinations performed: body weight, macroscopic observations, section (on dead aninals) - Statistics:
- LD50 values were calculated according using Probit analysis (after Linder & Weber). Confidence intervals were calculated according to Cavalli-Sforza.
Results and discussion
- Preliminary study:
- Not relevant
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 9 187 mg/kg bw
- 95% CL:
- ca. 8 383 - ca. 10 067
- Mortality:
- 6300 mg/kg bw: 0 out of 10
8000 mg/kg bw: 2 out of 10
10000 mg/kg bw: 7 out of 10
15000 mg/kg bw: 10 out of 10 - Clinical signs:
- other: Affected animals showed difficulties with breathing and a disturbed equilibrium.
- Gross pathology:
- Deceased animals showed reddening of the stomach and intestinal slime layer. Surviving animals did not show macroscopic abberations.
- Other findings:
- No data
Any other information on results incl. tables
See attached full study report for raw data.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the test conditions, the LD50 of Locron P towards female SPF-Wistar rats is 9187 mg/kg bw therefore it is not classified according to the criteria of the Annex VI of the Regulation EC No. 1272/2008 (CLP) and to the GHS.
- Executive summary:
The toxicity of Locron P towards female SPF-Wistar rats was investigated in an acute oral toxicity study comparable in methodology to OECD Guideline 401. The substance was administered to groups of ten animals at concentrations of 6300, 8000, 10000 and 15000 mg/kg bodyweight followed by a 14 -day post-dosing observation period.
Mortality was observed at 8000, 10000 and 15000 mg/kg bw: 2/10, 7/10 and 10/10, respectively. Affected animals showed difficulties with breathing and a disturbed equilibrium. Deceased animals showed reddening of the stomach and intestinal slime layer. Surviving animals did not show macroscopic abberations.
Under the test conditions, the LD50 of Locron P was found to be 9187 mg/kg bw (8383 - 10067 mg/kg bw) therefore it is not classified according to the criteria of the Annex VI of the Regulation EC No. 1272/2008 (CLP) and to the GHS.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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