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EC number: 234-933-1 | CAS number: 12042-91-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Particle size distribution (Granulometry)
Administrative data
Link to relevant study record(s)
- Endpoint:
- particle size distribution (granulometry)
- Data waiving:
- other justification
- Justification for data waiving:
- other:
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 06 July 2010- 07 July 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- This study has been performed according to OECD and international guidelines, and according to GLP principles. The test substance is adequately characterised. Therefore full validation applies.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- ISO 13320 (Particle size analysis - Laser diffraction methods)
- Version / remarks:
- 2009
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: CIPAC MT 187
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- Laser scattering/diffraction
- Type of particle tested:
- primary particle
- Type of distribution:
- volumetric distribution
- Mass median aerodynamic diameter:
- 281 µm
- Geometric standard deviation:
- 4.58
- Percentile:
- D10
- Mean:
- < 57.1 µm
- St. dev.:
- 0.76
- Percentile:
- D50
- Mean:
- < 201 µm
- St. dev.:
- 3.14
- Percentile:
- D90
- Mean:
- < 488 µm
- St. dev.:
- 9.81
- Conclusions:
- The test substance contains a limited fraction of particles fine enough to be inhaled and reach the thoracic fraction.
Dust explosion potential should be considered. - Executive summary:
The test substance was first examined under microscope, and described as a coarse white powder, consisting of single crystalline particles, of irregular shape.
Manual sieve analysis indicated that 100% by weight of the sample had a particle size of < 2000 µm. Therefore the sample was tested as received.
Using the laser diffraction test (dry method), the distribution was Gaussian, with a Mass Median Aerodynamic Diameter (MMAD) of 281 µm.
With regard to inhalation potential, about 22% of total particles are smaller than 100 μm, and ca 0.75% could reach the thoracic fraction (<10 μm).
Fine particles relevant to dust explosion hazard (<500 μm) account for 90%.
Referenceopen allclose all
Standard visual observation
Sample observed to be a coarse, white powder.
Observation at 100 x magnification
The particles appeared to crystalline and of irregular shape. The smallest individual particle size was approximately 15 μm and the largest individual size was approximately 597 μm.
Observation at 400 x magnification
The sample was observed to be made up of single crystalline particles.
Manual Sieve Analysis
Manual sieve analysis indicated that 100% by weight of the sample had a particle size of < 2000 µm. Therefore the sample was tested as received.
Laser diffraction
run n° | 1 | 2 | 3 | 4 | 5 | Average* | SD | RSD** |
d10 | 56.254 | 58.238 | 56.287 | 57.063 | 57.566 | 57.064 | 0.76 | 1.33% |
d50 | 197.068 | 206.622 | 199.600 | 201.398 | 201.760 | 201.286 | 3.14 | 1.56% |
d90 | 477.392 | 484.893 | 502.818 | 497.346 | 480.671 | 488.148 | 9.81 | 2.01% |
MMAD | 275.191 | 288.532 | 278.727 | 281.238 | 281.743 | 281.08 | 4.39 | 1.56% |
GSD | 129.650 | 143.488 | 133.067 | 135.166 | 136.324 | 4.58 | 3.38% |
* Average result was calculated from the entirety of data captured in each run and is not a simple arithmetic mean.
** Coefficient of variation for d50 is less than 3%; d10 and d90 are less than 5%. Thus repeatability of the characteristic particles in the size distribution are within the acceptable limits as per the ISO 13320 test standard.
The graph of volume % versus particle diameter shows a Gaussian-type distribution.
For the thresholds relevant to inhalation potential:
Inhalable fraction (< 100.237 μm): 21.75 %
Thoracic fraction (< 10.024 μm): 0.75 %
Respirable fraction (< 4.477 μm): 0.04 %
A threshold of 500 μm is generally assumed to be of concern for dust explosion potential; the corresponding corrected fraction (< 502.377 μm) accounts for 90.1%.
Description of key information
From the various processes of the individual registrants, particle size distribution can show different profiles. Therefore the CSA was performed for both high and low dustiness parameter, and the individual data are not deemed necessary.
Additional information
Experimental data is provided as supporting information on the representative sample tested for physico-chemical properties.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.