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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Study only available as summary in the ECB iuclid dataset for 3-chloropropane-1,2-diol (European Commission-European Chemicals Bureau-19 Feb 2000-http://ecb.jrc.eu/esis/index.php?GENRE=CASNO&ENTREE=9624-2).

Data source

Reference
Title:
The comparative effects of|1,2-dibromo-3-chloropropane (DBCP) and his metabolites,|3-chloro-1,2-propaneoxide (Epichlorohydrin),|3-chloro-1,2-propanediol (alpha-Chlorohydrin), and oxalic|acid, on the urogenital system of male rats
Author:
Kluwe W.M.
Year:
1983
Bibliographic source:
Toxicol. Appl. Pharmacol., 70, 67-86.

Materials and methods

Principles of method if other than guideline:
other
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
3-chloropropane-1,2-diol
EC Number:
202-492-4
EC Name:
3-chloropropane-1,2-diol
Cas Number:
96-24-2
Molecular formula:
C3H7ClO2
IUPAC Name:
3-chloropropane-1,2-diol

Test animals

Species:
rat

Administration / exposure

Route of administration:
subcutaneous

Results and discussion

Applicant's summary and conclusion