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EC number: 202-492-4 | CAS number: 96-24-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2010-01-18 to 2010-04-14
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study performed according to OECD 301b and EU C.4.C under GLP conditions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-C (Determination of the "Ready" Biodegradability - Carbon Dioxide Evolution Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 3-chloropropane-1,2-diol
- EC Number:
- 202-492-4
- EC Name:
- 3-chloropropane-1,2-diol
- Cas Number:
- 96-24-2
- Molecular formula:
- C3H7ClO2
- IUPAC Name:
- 3-chloropropane-1,2-diol
- Details on test material:
- - Name of test material (as cited in study report): 3-Chloro-1,2 propane diol
- Physical state: Liquid
- Composition of test material, percentage of components: 3-chloro-1,2-propane diol, > 98%
- Analytical purity: 99,3% (GC)
- Purity test date: 99,3% (GC)
- Lot/batch No.: 5225
- Expiration date of the lot/batch: 17/11/2010
- Storage condition of test material: Stored in a closed vessel at room temperature protected from light
- Other: date of production: 17 Nov 2009
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic (adaptation not specified)
- Details on inoculum:
- - Source of inoculum/activated sludge: Activation basin of the ESN (Stadtentsorgung Neustadt) seawage treatment plant, Im Altenschemel, NW-Lachen-Speyerdorf
- Pretreatment: the sludge was filtrated, washed with tap water twice, then washed with and re-suspended in test medium. It was then aerated for ≥12 hours. The dry matter was determined with 3780 mg suspended solids/litre
- Concentration of inoculum during experiment: 25 mg/L - Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 61.63 mg/L
- Based on:
- test mat.
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- TEST CONDITIONS
- Composition of medium: solution A (10 mL) + solution B (1 mL) + solution C (1 mL) + solution D (1 mL) + H2O demin. (1000 mL)
- Test temperature: 22 ± 2 °C
- pH: 7.1-7.3
- Aeration of dilution water: purified (by activated charcoal), CO2-scrubbed, moistened air
TEST SYSTEM
- Number of culture flasks/concentration: 2
- Method used to create aerobic conditions: aeration with purified (by activated charcoal), CO2-scrubbed, moistened air
- Measuring equipment: carbon analyser TOC multi N/C 2100S, Analytik Jenar
- Details of trap for CO2 and volatile organics if used: Two scrubbers containing 100 mL in 0.25-m-NaOH each
SAMPLING
- Sampling frequency: on day 0, 2, 4, 7, 9, 11, 14, 18, 22 and 29
- Sampling method: The emitted CO2 was trapped in 0.25 M NaOH. Two scrubbers containing 100 mL each were connected in series to the test vessels. the initial inorganic carbon (IC) content of the 0.25 M NaOH was seperately determined in each flask. From each front scrubber flask, ten samples were taken in order to determine the emitted CO2 on days 0, 2, 4, 7, 9, 11, 14, 18, 22 and 29. the sample volume was 1 mL. The resulting change in the volume of the front flask was considered in the calculation of emitted CO2. On day 28.5 mL HCl 2-M was added to each test flasks in order to drive off dissolved CO2. On day 29, samples from both scrubber flasks were taken.
CONTROL AND BLANK SYSTEM
- Inoculum blank: 2, containing mineral medium and inoculum
- Abiotic sterile control: 1, containing test item, mineral medium and HgCl2
- Toxicity control: 1, containing test item, positive control, mineral medium and inoculum
- Positive control: 2, containing positive control, mineral medium and inoculum
Reference substance
- Reference substance:
- aniline
Results and discussion
- Preliminary study:
- Not applicable
- Test performance:
- All validity criteria were met:
IC content of test item solution in medium: <1% (criterion: <=5% of TC)
CO2 emitted by the controls: 8.2 mg/L (criterion: <70 mg/L)
Difference within replicates: 1.2% (criterion: <=20%)
Degradation of positive control >60%: 9 days (criterion: <14 days)
Degradation in the toxicity flask on day 14: 62% (criterion: >25%)
% Degradationopen allclose all
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 77.1
- Sampling time:
- 28 d
- Remarks on result:
- other: Mean of two replicates (76.5% and 77.7%)
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 66.5
- Sampling time:
- 18 d
- Remarks on result:
- other: End of 10-day window period (mean of two replicates, 64.6% and 68.4%). 10 day window began on day 7
- Details on results:
- Degradation behaviour of positive control and toxicity control was normal. Abiotic degradation was 3%. Both replicates of the test item showed very good correspondence. Degradation in the toxicity flask lay between degradation in the positive controls and degradation in the test flasks, as was expected. If degradation in the toxicity flask is below 25% after 14 days, the test item can be considered as toxic towards the inoculum. This was not the case as degradation was 62% after 14 days.
BOD5 / COD results
- Results with reference substance:
- On day 29, the mean degradation was 82.4%.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- The 10-day-window began on day 7 (9.7 and 12.6% degradation), at its end, 66.5% degradation was reached (64.6 and 68.4%), surpassing the pass level of 60% given in the OECD guideline. The test item 3-Chloro-1,2 propane diol is considered as "readily biodegradable".
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