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EC number: 202-180-8 | CAS number: 92-70-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: All information on this study, including the reliability grade, is derived from OECD SIDS 3-hydroxy-2-naphthoic acid CAS: 92-70-6 dated 2004-11-23, as the complete study report is not at hand. The testing laboratory report no. is HRI 10-1636.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Guideline 415 (One-Generation Reproduction Toxicity Study)
- Deviations:
- no
- GLP compliance:
- yes
- Limit test:
- no
Test material
- Reference substance name:
- 3-hydroxy-2-naphthoic acid
- EC Number:
- 202-180-8
- EC Name:
- 3-hydroxy-2-naphthoic acid
- Cas Number:
- 92-70-6
- Molecular formula:
- C11H8O3
- IUPAC Name:
- 3-hydroxynaphthalene-2-carboxylic acid
- Details on test material:
- - Name of test material (as cited in OECD SIDS): 3-Hydroxy-2-naphtoic acid
Test material purity 99.2%,
impurity: 2-naphthol, 0.1%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 0.5% sodium CMC (carboxymethyl cellulose) solution
- Analytical verification of doses or concentrations:
- not specified
- Details on mating procedure:
- Mating period: max 3 weeks (1:1, until pregnancy or until three weeks had elapsed).
- Duration of treatment / exposure:
- males: for 10 weeks prior to mating, during the mating period and until the day before necropsy (98 days);
females: for 2 weeks prior to mating, during mating and gestation and until day 20 of lactation.
Explanatory note (not specified in the OECD SIDS): Based on the biology of the laboratory rat the female exposure period was as follows:
treatment prior to mating = 2 weeks
mating period = 0-3 weeks
gestation/pregnancy = 3 weeks
lactation period = 3 weeks
total treatment period females = 8 to 11 weeks - Frequency of treatment:
- daily (once per day)
- No. of animals per sex per dose:
- 25 per sex per dose group (parental animals)
Results and discussion
Results: maternal animals
Effect levels (maternal animals)
- Dose descriptor:
- NOEL
- Effect level:
- 50 other: mg/kg bw/day (actual dose received by parental animals P)
- Basis for effect level:
- other: other:
Results (fetuses)
- Details on embryotoxic / teratogenic effects:
- Embryotoxic / teratogenic effects:yes
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Any other information on results incl. tables
There was an increase in the incidence of offspring with external malformations such as kinked tail, brachyury, brachyury with kink or microphthalmus in the high-dose group. Detailed study results including parental toxic effects, reproductive performance and embryotoxic/teratogenic effects are given in Endpoint study record "7.8.1 Toxicity to reproduction: KEY_2004_OECD SIDS_CAS_92-70-6_fert"
Applicant's summary and conclusion
- Conclusions:
- The no-observed-effect-level (NOEL) for systemic toxicity in parental female animals was 50 mg/kg/day, because of forestomach lesions and adverse effects on bodyweight gain at 200 mg/kg/day. For developmental toxicity and teratogenicity, the NOEL was set at 50 mg/kg/day, because of growthretardation (bodyweight of pups lower than concurrent controls) and malformations (e.g. brachyury, kinked tail, microphthalmus in pups from a limited number of litters) at 200 mg/kg/day. The growth retardation of these pups may have been related to suppressed lactation suggested by the authors of this study. More comprehensive conclusions on the entire study are given in Endpoint study record "7.8.1 Toxicity to reproduction: KEY_2004_OECD SIDS_CAS_92-70-6_fert".
- Executive summary:
A comprehensive executive summary is given in Endpoint study record "7.8.1 Toxicity to reproduction: NONKEY_415_2004_OECD SIDS_CAS_92-70-6_fert".
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