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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

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Additional information

NON-HUMAN TOXICITY EXCERPTS:

A GROUP OF MICE WERE PAINTED WITH A 0.25% SOLN OF P-QUINONE IN BENZENE

EVERY 1 OR 2 DAYS. OF 44 MICE THAT SURVIVED MORE THAN 200 DAYS, 3

DEVELOPED SKIN PAPILLOMAS, 1 DEVELOPED A SKIN CARCINOMA & 5 DEVELOPED

LUNG ADENOCARCINOMAS. WHEN 0.1% SOLN WAS USED, 41 MICE SURVIVED MORE THAN

200 DAYS, & 6 DEVELOPED SKIN PAPILLOMAS, 2 DEVELOPED SKIN CARCINOMAS

&amp; 10 DEVELOPED LUNG ADENOCARCINOMAS (P < 0.05). OF 46 SURVIVING

CONTROLS TREATED WITH BENZENE, 1 DEVELOPED SKIN PAPILLOMA, &amp; 2

DEVELOPED LUNG ADENOCARCINOMAS (THE WORKING GROUP NOTED THAT THE SEX &amp;

STRAIN OF ANIMALS &amp; DURATION OF EXPT WERE NOT SPECIFIED).[IARC.

Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to

Man. Geneva: World Health Organization, International Agency for Research

on Cancer, 1972-PRESENT. (Multivolume work). Available at:

http://monographs.iarc.fr/index.php, p. V15 258 (1977)]

GROUP OF 25 MICE (SEX &amp; STRAIN UNSPECIFIED) WERE EXPOSED /BY

INHALATION/ TO 5 MG PARA-QUINONE IN 130 L CHAMBER FOR 1 HR, 6 TIMES/WK; 25

MICE WERE UNTREATED ... . IN 11 TREATED MICE THAT SURVIVED MORE THAN 100

DAYS, 2 LUNG ADENOCARCINOMAS WERE OBSERVED. AMONG 12 CONTROLS THAT DIED

AFTER MORE THAN 100 DAYS, 2 LUNG ADENOMAS WERE OBSERVED. IN ANOTHER EXPT

CARRIED OUT UNDER SAME CONDITIONS OF EXPOSURE, 2 LUNG ADENOCARCINOMAS WERE

FOUND IN 25 TREATED MICE, COMPARED WITH 1 LUNG ADENOMA AMONG 25 CONTROLS.

THE SAME EXPT WAS REPEATED &amp; 2 LUNG ADENOCARCINOMAS WERE OBSERVED IN

25 MICE &amp; 1 LUNG ADENOMA IN 25 CONTROLS.[IARC. Monographs on the

Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World

Health Organization, International Agency for Research on Cancer,

1972-PRESENT. (Multivolume work). Available at:

http://monographs.iarc.fr/index.php, p. V15 259 (1977)]

A GROUP OF 24 RATS (15 WISTAR STRAIN &amp; 9 HYBRIDS), WEIGHING ABOUT 200

G EACH, WERE INJECTED SC WITH 0.5 ML SOLN OF P-QUINONE IN PROPYLENE GLYCOL

AT WEEKLY INTERVALS. CONCN GIVEN DURING THE FIRST 53 DAYS WAS 1%; THIS WAS

REDUCED TO 0.2% FROM DAYS 54-173 &amp; AGAIN INCREASED TO 0.4% AFTER 173

DAYS. 17 RATS SURVIVED THE INJECTION PERIOD OF 394 DAYS &amp; RECEIVED A

TOTAL OF 32 INJECTIONS (P-QUINONE 81 MG, PROPYLENE GLYCOL 16.5 ML) DURING

THIS PERIOD. INJECTION SITE FIBROSARCOMAS DEVELOPED IN 2 RATS. NO LOCAL

TUMORS WERE OBSERVED AMONG 11 RATS OF SAITAMA MIXED STRAIN INJECTED WEEKLY

WITH 1 ML PROPYLENE GLYCOL FOR 15 MO, THEN 0.5 ML, &amp; SURVIVING 300 OR

MORE DAYS (P > 0.05).[IARC. Monographs on the Evaluation of the

Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization,

International Agency for Research on Cancer, 1972-PRESENT. (Multivolume

work). Available at: http://monographs.iarc.fr/index.php, p. V15 259

(1977)]

Justification for classification or non-classification

There is inadequate evidence in experimental animals for the carcinogenicity of 1,4-benzoquinone. Overall evaluation: 1,4-Benzoquinone is not classifiable as to its carcinogenicity to humans (Group 3).