Terephthaloyl dichloride

Repeated dose toxicity: inhalation

Administrative data

Endpoint:

short-term repeated dose toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1971

Report date:

1971

Materials and methods

Principles of method if other than guideline:

Six male rats were exposed whole body to the test substance for four hours per day for ten days. Six control rats were exposed to air for the same period of time. Gross and histopathologic examinations were performed on three rats from each group after the last exposure and 14 days post-exposure.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Terephthaloyl dichloride

EC Number:

202-829-5

EC Name:

Terephthaloyl dichloride

Cas Number:

100-20-9

Molecular formula:

C8H4Cl2O2

IUPAC Name:

benzene-1,4-dicarbonyl dichloride

Constituent 2

Reference substance name:

Terephthaloyl chloride

IUPAC Name:

Terephthaloyl chloride

Details on test material:

- Purity: 99.9%

Test animals

Species:

rat

Strain:

other: ChR-CD

Sex:

male

Administration / exposure

Route of administration:

inhalation: aerosol

Type of inhalation exposure:

whole body

Vehicle:

other: air (nitrogen carried aerosol into test chamber where it was then mixed with additional oxygen and diluting air to achieve a 20% O2 (v/v) level)

Analytical verification of doses or concentrations:

yes

Duration of treatment / exposure:

4 hours

Frequency of treatment:

One time per day for 10 days

Doses / concentrations

Dose / conc.:

0.087 other: ± 0.010 mg/L

Remarks:

average concentration

No. of animals per sex per dose:

6

Control animals:

yes, sham-exposed

Results and discussion

Results of examinations

Description (incidence and severity):

During exposure period rats did not gain weight normally; during post exposure weight gain was normal.

Description (incidence and severity):

No significant histopathological changes.

Effect levels

Dose descriptor:

dose level:

Effect level:

0.087 mg/L air

Sex:

male

Basis for effect level:

other: suppressed growth rate during exposures; growth rate normal during recovery

Target system / organ toxicity

Critical effects observed:

no

Applicant's summary and conclusion

Conclusions:

In rats exposed by inhalation to 0.087 mg/L for four hours for ten days weight gain suppression was observed during exposure and was normal during recovery. No significant treatment related histophathological changes were found.

Executive summary:

Six male rats were exposed whole body to 0.087 mg/L of the test substance for four hours per day for ten days. Six control rats were exposed to air for the same period of time. Gross and histopathologic examinations were performed on three rats from each group after the last exposure and 14 days post-exposure. In rats exposed by inhalation to 0.087 mg/L for four hours for ten days weight gain suppression was observed during exposure and was normal during recovery. No significant treatment related histophathological changes were found.