Terephthaloyl dichloride

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Remarks:

One animal per group.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1971

Report date:

1971

Materials and methods

Principles of method if other than guideline:

The test substance, as a suspension in corn oil, was administered by gavage to young adult male rats in a single dose (1 rat/dose level). Dose levels were 670, 1500, 2500, 3400, 5000, 7500 mg/kg. Survivors were sacrificed 14 days later. Animals were observed for toxic signs, body weight changes, mortality and moribunditity.

GLP compliance:

not specified

Test type:

standard acute method

Test material

Test material information

Constituent 1

Reference substance name:

Terephthaloyl dichloride

EC Number:

202-829-5

EC Name:

Terephthaloyl dichloride

Cas Number:

100-20-9

Molecular formula:

C8H4Cl2O2

IUPAC Name:

benzene-1,4-dicarbonyl dichloride

Constituent 2

Reference substance name:

Terephthaloyl chloride

IUPAC Name:

Terephthaloyl chloride

Details on test material:

- Purity: 99.9%

Test animals

Species:

rat

Strain:

other: ChR-CD

Sex:

male

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Age at study initiation: Young adult

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

corn oil

Details on oral exposure:

VEHICLE
10% suspension for concentrations of 670-2250 mg/kg.
20% suspension for concentrations of 3400-7500 mg/kg.

Doses:

670, 1500, 2250, 3400, 5000, 7500 mg/kg. The highest dose was administered in divided dose.

No. of animals per sex per dose:

1 rat/dose

Control animals:

not specified

Details on study design:

- Duration of observation period following administration was 14 days.
- Frequency of observations and weighing: Daily
- Necropsy of survivors performed: Not reported
- Other examinations performed: Clinical signs and body weight.

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

other: approximate lethal dose (ALD)

Effect level:

5 000 mg/kg bw

Mortality:

At 7500 mg/kg death at day one.
At 5000 mg/kg death at day six.

Clinical signs:

other: Lethal doses: Discomfort and inactivity after dosing. Irregular respiration on day of dosing. Heavy breathing, weakness, blood in urine, absence of faeces for 2 days. Non-lethal doses: Discomfort and inactivity after dosing. Irregular respiration on day o

Gross pathology:

Not reported.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

ALD = 5000 mg/kg

Executive summary:

The test substance, as a suspension in corn oil, was administered by gavage to young adult male rats in a single dose (1 rat/dose level). Dose levels were 670, 1500, 2500, 3400, 5000, 7500 mg/kg. Survivors were sacrificed 14 days later. Animals were observed for toxic signs, body weight changes, mortality and moribunditity. The ALD was 5000 mg/kg.