Registration Dossier
Registration Dossier
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EC number: 220-237-5 | CAS number: 2680-03-7
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable publication which meets basic scientific principles.
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicologic Investigations of Dimethylacrylamide in Mice
- Author:
- Hayashi E, Kunitomo M, Terada M, Tomita T
- Year:
- 1 974
- Bibliographic source:
- The Journal of Hygienic Chemistry 20 (6) 317-321
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Male and female mice of ddyS strain weighing 18-22g received various doses of dimethylacrylamide in aqueous solution through subcutaneous injection. The animals were observed frequently for any changes in gross appearance or behavior for 72 hr after the treatment. LD50 was calculated by the method of Litchfield and Wilcoxon.
Test material
- Reference substance name:
- N,N-dimethylacrylamide
- EC Number:
- 220-237-5
- EC Name:
- N,N-dimethylacrylamide
- Cas Number:
- 2680-03-7
- Molecular formula:
- C5H9NO
- IUPAC Name:
- N,N-dimethylacrylamide
Constituent 1
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 580 mg/kg bw
- Based on:
- test mat.
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 590 mg/kg bw
- Based on:
- test mat.
Any other information on results incl. tables
Following a slight increase in sensitivity to stimuli, gross general weakness was observed in the treated animals with disturbed gait and stance when walking. They lay down gradually on stomach with the eyes closed and were killed within 24 hr. Increased secretation from glans, diarrhea and tremor were not developed.
Applicant's summary and conclusion
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