N,N-dimethylacrylamide

Endpoint summary

Description of key information

The oral LD50 was >215 and <464 mg/kg bw, the inhalation LC50 (after 1 h exposure) was >3.16 mg/L and the dermal LD50 was 500-2000 mg/kg bw.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion

Endpoint conclusion:

adverse effect observed

Acute toxicity: via inhalation route

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed

Acute toxicity: via dermal route

Endpoint conclusion

Endpoint conclusion:

adverse effect observed

Additional information

Oral toxicity

In a study comparable to OECD guideline 401, Sprague-Dawley rats (males and females, 5 per sex per dose) were administered N,N-dimethylacrylamide at dose levels of 46.4, 100, 215 and 464 mg/kg bw by single dose (in distilled water by gavage (USEPA, 1992)). All animals of the high dose group (464 mg/kg bw) were found dead 24 hours after dosing. No deaths occurred in the other dose groups. At 46.4, 100 and 215 mg/kg bw, all animals appeared slightly depressed at four hours. After 24 hours, all animals appeared normal. At 464 mg/kg bw, slight depression was observed in all animals immediately post dosing. Hunching, depression, and ataxia or ptosis at one hour preceded death at 24 hours in all animals. No observable gross pathology was noted at death or termination. The LD50 was >215 and <464 mg/kg bw.

 

Inhalation toxicity

In an inhalation hazard test according to US OSHA Regulation 29 CFR 1910.1200, Sprague-Dawley rats (5/sex) were exposed to N,N-dimethylacrylamide as vapour for 1 hour at a measured concentration of 3.16 mg/L (776 ppm, the highest achievable vapour concentration at 35 ºC) followed by a 14-day observation period (USEPA, 1998). No mortality occurred during the study. Fur coated with feces/urine was observed in all animals at 1 hour after exposure. For the remainder of the study, all animals appeared normal. Body weight gain of surviving animals was unaffected by the administration of the test substance. The gross necropsy conducted on each animal at termination of the study revealed no observable abnormalities, except for red lungs in three females. The LC50 was >3.16 mg/L.

 

Dermal toxicity

In a thirteen-week dermal toxicity study comparable to OECD guideline 411, 2/20 female rats exposed to 500 mg/kg bw N,N-dimethylacrylamide died within the first week of dosing (USEPA, 1996). Based on this the LD50 can be assumed to be 500 -2000 mg/kg bw.

Justification for classification or non-classification

Based on the available data, N,N-dimethylacrylamide has to be classified for acute oral and dermal toxicity. According to Directive 67/548/EEC, classification with Xn, R21/22 is warranted. According to the EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008, the classification is H301, Cat. 3 and H311, Cat. 3.