Registration Dossier
Registration Dossier
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EC number: 238-056-5 | CAS number: 14205-39-1
Endpoint summary
Administrative data
Description of key information
Oral (Rat-Wistar, non-GLP): LD50 = 1760 mg/kg
[Bayer AG, Report dated 1983-06-30]
Inhalative (Rat-Wistar, non-GLP): LC50 > 23 mg/m³
[Bayer AG, Report No. 11752, 1983-04-27]
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 1 760 mg/kg bw
Additional information
The acute oral as well as the acute inhalation toxicity of methyl 3 -aminocrotonate was studied in male and female rats.
The acute oral LD50 was determined to be 1760 mg/kg.
The acute 4 h-LC50 was determined to be > 23 mg/m3, the maximal technically feasible dust concentration at which no mortality and no symptoms occurred.
Justification for classification or non-classification
Based on the study results methyl 3 -aminocrotonate has to be classified according to Directive 67/548/EEC and Regulation (EC) No. 1272/2008 (CLP) as harmfull if swallowed (Xn, R22) or as acute oral toxic, category 4 (H302), respectively.
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