Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 701-004-1 | CAS number: -
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Irritation was recorded in an 10-grade scale which is not comparable to the Draize score. No information about volumes and concentrations administered. The results of the skin irritation test, that was performed in parallel, raises some questions on the substance identity and reliability.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Range finding toxicity data: List VI
- Author:
- Smyth H.F. et al.
- Year:
- 1 962
- Bibliographic source:
- J. Amer. Ind. Hyg. Assoc. J. 23: 95
- Title:
- Range finding toxicity data: List VII
- Author:
- Smyth H.F. et al.
- Year:
- 1 969
- Bibliographic source:
- J. Amer. Ind. Hyg. Assoc. J. 30: 470
Materials and methods
- Principles of method if other than guideline:
- Method is described in the publication of Smyth et al. (1962)
Eye injury is recorded in a 10-grade ordinal series and is based upon the degree of corneal necrosis: Grade 1: very small area of necrosis resulting from 0.5 ml of undiluted chemical; Grade 5: severe burn from 0.005 ml; Grade 10: severe burn from 0.5 ml of a 1% solution. - GLP compliance:
- no
Test material
- Reference substance name:
- Cyclopentene
- EC Number:
- 205-532-9
- EC Name:
- Cyclopentene
- Cas Number:
- 142-29-0
- Molecular formula:
- C5H8
- IUPAC Name:
- cyclopentene
- Details on test material:
- no further data available
Constituent 1
Test animals / tissue source
- Species:
- rabbit
Test system
- Amount / concentration applied:
- - Amount(s) applied (volume or weight with unit): various (no further details available)
- Concentration (if solution): various (no further details available)
Results and discussion
In vivo
Results
- Irritation parameter:
- other: 10-grade ordinal series
- Basis:
- mean
- Time point:
- other: no data
- Score:
- 5
- Max. score:
- 10
- Reversibility:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
