Registration Dossier
Registration Dossier
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EC number: 701-004-1 | CAS number: -
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Not sufficient for assessment;
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Range finding toxicity data: List VI
- Author:
- Smyth H.F. et al.
- Year:
- 1 962
- Bibliographic source:
- J. Amer. Ind. Hyg. Assoc. J. 23: 95
- Reference Type:
- publication
- Title:
- Range finding toxicity data: List VII
- Author:
- Smyth H.F. et al.
- Year:
- 1 969
- Bibliographic source:
- J. Amer. Ind. Hyg. Assoc. J. 30: 470
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Method described in the publication of Smyth et al. (1962)
Application of undiluted sample
Primary skin irritation is recorded in a 10-grade ordinal series and is based upon the severest reaction that develops on the clipped skin of each of the animals. Grade 1:no irritation; Grade 2: least visible capillary injection from the undiluted chemical; Grade 6: necrosis from the undiluted chemical; Grade 10 necrosis from 0.01% solution.
Restrictions/deviations compared to an OECD 404 guideline study:
no post-exposure observation time;
Irritation was recorded in an 10-grade scale which is not comparable to the Draize score;
no description of the test material - GLP compliance:
- no
Test material
- Reference substance name:
- Cyclopentene
- EC Number:
- 205-532-9
- EC Name:
- Cyclopentene
- Cas Number:
- 142-29-0
- Molecular formula:
- C5H8
- IUPAC Name:
- cyclopentene
- Details on test material:
- no further data available
Constituent 1
Test animals
- Species:
- rabbit
Test system
- Type of coverage:
- open
- Preparation of test site:
- other: clipped
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.01 ml
- Concentration (if solution): undiluted - Duration of treatment / exposure:
- 24 hour(s)
- Observation period:
- none
- Number of animals:
- 5
- Details on study design:
- SCORING SYSTEM:
10 grades:
Grade 1:no irritation; Grade 2: least visible capillary injection from the undiluted chemical; Grade 6: necrosis from the undiluted chemical; Grade 10 necrosis from 0.01% solution.
Results and discussion
In vivo
Results
- Irritation parameter:
- other: 10 grade ordinal series
- Basis:
- mean
- Time point:
- other: within 24 hours
- Score:
- 5
- Max. score:
- 10
- Reversibility:
- no data
Any other information on results incl. tables
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
