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EC number: 253-455-4 | CAS number: 37310-83-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2012-12-05 to 2012-12-14
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: according to GLP, OECD and EC guidelines
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 438 (Isolated Chicken Eye Test Method for Identifying Ocular Corrosives and Severe Irritants)
- Version / remarks:
- adopted 07 September 2009
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: Commission Regulation (EU) No 1152/2010 of 08 December 2010 amending, Regulation (EC) No 440/2008 (REACH) B.48
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- UVCB: not applicable
- IUPAC Name:
- UVCB: not applicable
- Reference substance name:
- UVCB: not applicable
- IUPAC Name:
- UVCB: not applicable
- Reference substance name:
- 9-Octadecen-1-ol, (Z)-, phosphate
- EC Number:
- 253-455-4
- EC Name:
- 9-Octadecen-1-ol, (Z)-, phosphate
- Cas Number:
- 37310-83-1
- Molecular formula:
- C18H37O4P
- IUPAC Name:
- [(9Z)-octadec-9-en-1-yloxy]phosphonic acid
- Test material form:
- liquid: viscous
Constituent 1
Constituent 2
Constituent 3
Test animals / tissue source
- Species:
- other: not applicable: Isolated chicken eyes (ROSS 308)
- Strain:
- other: not applicable
- Details on test animals or tissues and environmental conditions:
- Chicken heads collection and transport
Species of chicken: ROSS 308
Source: TARAVIS KFT. 9600 Sárvár, Rábasömjéni út. 129. Hungary
The age and weight of the chickens used for this study were that of spring chickens traditionally processed by a poultry slaughterhouse
(i.e., approximately 7 weeks old, 1.5 – 2.5 kg). Head collection was performed by a slaughter house technician. The heads were transported to TOXI-COOP ZRT. at the earliest convenience for use approximately within 2 hours from collection. All eyes used in the assay were from the same groups of eyes collected on one specific day. After collection, the heads were inspected for appropriate quality and wrapped with paper moistened with saline, then placed in a plastic box that can be closed (4-5 heads/box).
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: not applicable; however, eyes for positive and negative control were used
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.2 g
Test item was spread evenly on a small piece (approximately 2 cm2) of flexible plastic film to be applied directly onto the cornea. - Duration of treatment / exposure:
- After carefully covering the whole cornea with the test substance an exposure period of 10 seconds was applied.
Subsequently, the plastic film was removed from surface of the cornea carefully, taking care not to damage or touch the cornea with the application
equipment. - Observation period (in vivo):
- The control and test eyes were evaluated pre-treatment and at approximately 30, 75, 120, 180 and 240 minutes after the post-treatment rinse.
Minor variations within ±5 minutes were considered acceptable.
The cornea thickness and cornea opacity were measured at all time points. Fluorescein retention was measured on two occasions, at base line (t=0) and 30 minutes after the posttreatment rinse. - Number of animals or in vitro replicates:
- The treatment group and the concurrent positive control consisted of three eyes. The negative control group consisted of one eye.
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing: cornea surface was rinsed thoroughly with 20 mL saline solution at ambient temperature,
- Time after start of exposure: 10 seconds
SCORING SYSTEM:
Evaluation:
The endpoints evaluated were corneal opacity, swelling, fluorescein retention, and morphological effects (e.g., pitting or loosening of the epithelium).
Results from corneal opacity, swelling, and fluorescein retention were evaluated separately to generate an Isolated Chicken Eye (ICE) class for each
endpoint. The ICE classes for each endpoint were then combined to generate an Irritancy Classification for each test substance (regulatory EC/GHS
classification).
Severity of effects:
The effects were divided into four categories:
I = none
II = slight
III = moderate
IV = severe O
TOOL USED TO ASSESS SCORE: The cornea thickness and cornea opacity were measured at all time points. Fluorescein retention was measured on
two occasions, at base line (t=0) and 30 minutes after the post-treatment rinse.
Results and discussion
In vitro
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Value:
- 4
- Vehicle controls validity:
- not applicable
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- fluorescein retention score
- Value:
- 3
- Vehicle controls validity:
- not applicable
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- percent corneal swelling
- Remarks:
- at up to 75 min
- Value:
- 1
- Vehicle controls validity:
- not applicable
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- percent corneal swelling
- Remarks:
- at up to 240 min
- Value:
- 2
- Vehicle controls validity:
- not applicable
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- positive indication of irritation
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: corneal opacity score
- Basis:
- mean
- Remarks:
- ìsolated chicken eyes
- Time point:
- other: 30-75-120-180-240 min relative observation time
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritation parameter:
- other: corneal thickness
- Basis:
- mean
- Remarks:
- isolated chicken eyes
- Time point:
- other: 30-75-120-180-240 min relative observation time
- Score:
- >= 0 - <= 2
- Max. score:
- 2
- Reversibility:
- other: not applicable
- Remarks on result:
- other: The values are given in "% change of instrumental units in comparison to timepoint 0"
- Irritation parameter:
- other: fluorescein retention
- Basis:
- mean
- Remarks:
- isolated chicken eyes
- Time point:
- other: 30 min relative observation time
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- other: not applicable
- Irritant / corrosive response data:
- In this in vitro eye irritation study using the isolated chicken eyes test with Reaction product of oleyl alcohol with polyphosphoric acid, ocular
corrosion and severe irritation potential was observed. The test item was classified as corrosive/severely irritating, CLP Classification: Category 1. - Other effects:
- none
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye)
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In this In vitro eye corrosives and severe irritants study, using the Isolated Chicken Eyes model with Reaction product of oleyl alcohol with poly-
phosphoric acid, according to the guideline OECD 438 ocular corrosion and severe irritation potential was observed. Thus, according to Regulation (EC) No 1272/2008 Reaction product of oleyl alcohol with polyphosphoric acid causes serious damage to the eye and has to be classified into
Category 1. - Executive summary:
In this In vitro eye corrosives and severe irritants study, using the Isolated Chicken Eyes model with Reaction product of oleyl alcohol with poly- phosphoric acid, according to the guideline OECD 438 ocular corrosion and severe irritation potential was observed. Thus, according to Regulation (EC) No 1272/2008 Reaction product of oleyl alcohol with polyphosphoric acid causes serious damage to the eye and has to be classified into Category 1.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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