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EC number: 253-455-4 | CAS number: 37310-83-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2013-03-19 to 2013-04-03
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: CLP and Guideline compliant study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Version / remarks:
- , adopted 24th February 1987
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- Version / remarks:
- , 31.05.2008
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1200 (Acute Dermal Toxicity)
- Version / remarks:
- , adopted August, 1998
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Limit test:
- yes
Test material
- Reference substance name:
- UVCB: not applicable
- IUPAC Name:
- UVCB: not applicable
- Reference substance name:
- UVCB: not applicable
- IUPAC Name:
- UVCB: not applicable
- Reference substance name:
- 9-Octadecen-1-ol, (Z)-, phosphate
- EC Number:
- 253-455-4
- EC Name:
- 9-Octadecen-1-ol, (Z)-, phosphate
- Cas Number:
- 37310-83-1
- Molecular formula:
- C18H37O4P
- IUPAC Name:
- [(9Z)-octadec-9-en-1-yloxy]phosphonic acid
- Test material form:
- liquid: viscous
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Toxi-Coop Zrt. 1103 Budapest, Cserkesz u. 90.
- Age at study initiation: Young adult rats, females were nulliparous and non-pregnant
- Weight at study initiation: Male 230-248 g, Female 233-263 g
- Fasting period before study: food but not water was withheld overnight
- Housing during acclimasation: 3 animals/sex/cage and during the study: animals were housed individually
- Diet: ad libitum (ssniff® SM R/M-Z+H complete diet )
- Water: ad libitum
- Acclimation period: 5 days (males), 47 days (females)
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 3 °C
- Humidity (%): 30 - 70 %
- Air changes (per hr): 10-15 air exchanges/hour by central air-condition system.
- Photoperiod: Artificial light, from 6 a.m. to 6 p.m.
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: approximately 10 % of the total body surface
- The vial with the test item was opened shortly before being moistened and applied.
- Type of wrap if used: sterile gauze pad below a semi-occlusive plastic wrap
REMOVAL OF TEST SUBSTANCE
- residual test item was removed, using helianthi oleum raffinatum as an appropriate solvent
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amount applied: Limit test: 2000 mg/kg bw - Duration of exposure:
- single administration for 24 hours
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- not required
- Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: the body weight of all animals were recorded on day 0 (shortly before the treatment), on day 7 and on day 15 (with a precision of 1 g)
- Necropsy of survivors performed: yes
- Other examinations performed: Animals were observed individually 1 h and 5 h after dosing, and once each day for 14 days thereafter. Observations included the skin and fur, eyes and mucous membranes, and also respiratory, circulatory, autonomic and central nervous system, and somatomotor activity and behaviour pattern. Particular attention was directed to observation of tremors, convulsions, salivation, diarrhoea, lethargy, sleep and coma.
All animals were subjected to gross pathology. All animals were exsanguinated under isoflurane anaesthesia on day 15. After examination of the external appearance the cranial, thoracic and abdominal cavities were opened and the appearance of the tissues and organs were observed. All gross pathological changes were recorded for each animal on the post mortem record sheets. - Statistics:
- not applicable
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no mortality occured
- Clinical signs:
- other: General symptoms No behavioural changes or systemic toxic signs were noted during the study. Dermal irritation symptoms as erythema (redness), oedema and other signs were observed on the treatment site. The very slight (score 1) redness, well defined (sc
- Gross pathology:
- All animals survived until the scheduled necropsy on Day 15.
Slight hydrometra was observed in one female and moderate hydrometra was found in two females. Hydrometra was an indication for the sexual cycle of female animals and is a frequent observation in experimental rats with no toxicological meaning.
No macroscopic alterations due to the systemic toxic effects of the test item were found. - Other findings:
- none
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In this acute dermal toxicity study with the test item Reaction product of oleylalcohol with polyphosphoric acid, the obtained acute dermal LD50 value was higher than 2000 mg/kg bw in male and female Crl:(WI)BR rats.
- Executive summary:
A limit test was carried out. A single group of male and female animals (n=5 animals/sex) was exposed to Reaction product of oleylalcohol with polyphosphoric acid at 2000 mg/kg bw by dermal route. The test item was applied in its original form and left in contact with the skin for 24 hours, followed by a 14-day observation period.
The results of the study were summarised as follows:
No mortality occurred during the study.
Dose
2000 mg/kg bw
Male
5
Mortality
0/5
Female
5
Mortality
0/5
Neither male nor female animals treated at 2000 mg/kg bw showed behavioural changes and no systemic toxic signs were noted during the study.
The test item caused dermal irritation symptoms as slight to severe erythema, slight oedema and other signs as wounds, crusting and desquamation between Day 1 and Day 14 in males and between Day 1 and Day 11 in females.
Very slight body weight variations were observed in two females during first week and also in one out of the two females during second week.
The body weight development was undisturbed in all male animals.
No macroscopic alterations of organs and tissues referred to the systemic toxic effect of the test item were seen during the necropsy.
In this acute dermal toxicity study with the test item Reaction product of oleylalcohol with polyphosphoric acid, the obtained acute dermal LD50 value was higher than 2000 mg/kg bw in male and female Crl:(WI)BRrats.
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