Registration Dossier
Registration Dossier
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EC number: 255-485-3 | CAS number: 41669-30-1
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
No effects up to the limit of water solubility (OECD 203).
Key value for chemical safety assessment
Additional information
Since no studies investigating the short-term toxicity of isooctadecyl isooctadecanoate (CAS 41669-30-1) to fish are available, in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5 a read-across to the structurally related source substance 2-octyldodecyl isooctadecanoate (CAS 93803-87-3) was conducted. The source substance is representative to evaluate the short-term toxicity of isooctadecyl isooctadecanoate to fish. 2-octyldodecyl isooctadecanoate is characterized by the same fatty acid chain length (isooctadecanoic acid) and a similar branched alcohol component (2-octyldodecanol compared to isohexadecanol/isooctadecanol for the target substance). This read-across is justified in detail in the overall summary (IUCLID Section 6.1) and within the analogue justification in IUCLID Section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was used for the assessment.
The study with the read-across substance 2-octyldodecyl isooctadecanoate was conducted according to OECD 203 (GLP) investigating the short-term toxicity to fish (Cyprinus carpio) (Bogers, 1998). Water Accommodated Fractions (WAF) of nominal 10 and 100 mg/L were prepared and tested under static conditions. A chemical analysis of the test substance concentrations in the test vessels was not possible since no applicable method could be established due to the very low water solubility to detect test concentrations. No mortality was observed after 96 h and therefore a LL50 of > 100 mg/L was derived.
Based on the available result from one structurally related source substance (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which is characterized by a similar ecotoxicological profile and comparable structure, it can be concluded that isooctadecyl isooctadecanoate will not exhibit short-term effects to fish up to the limit of water solubility.
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