Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 903-945-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- from 03 jan 1990 to 19 sept 1990
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study, OECD 404 compliant.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Chlorodifluoroacetic acid
- EC Number:
- 200-928-8
- EC Name:
- Chlorodifluoroacetic acid
- Cas Number:
- 76-04-0
- Molecular formula:
- C2HClF2O2
- IUPAC Name:
- chloro(difluoro)acetic acid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Bancel (Albon - 26140 Saint Rambert d'Albon - France)
- Age at study initiation: adult, 3 males
- Weight at study initiation: 2.4 and 2.5 kg
- Housing: Individually in polystyrene cages (560 x 355 x 315 mm)
- Diet (e.g. ad libitum): 150 g pe animal and per day of rabbits food pellets (U.A.R, formula 112 - U.A.R, Villemoison - 91360 Epinay/Orge - France)
- Water (e.g. ad libitum): softened and filtered water (15 µm), ad libitum
- Acclimation period: 13 days before treatment
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 +/- 3°C
- Humidity (%): 30 to 70%
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12h/12h, lighting: 7h30 - 19h30
IN-LIFE DATES: From 03 jan 1990 To 05 jan 1990
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 14 days maximum
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: back and flanks
- % coverage: 6 cm²
- Type of wrap if used: perforated adhesive tape 10 cm width.
SCORING SYSTEM: EU
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- Animals were killed at 48 hours for human reason
- Remarks on result:
- other: Necrosis
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- > 3 - <= 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- Animals were killed at 48 hours for human reason
- Remarks on result:
- other: reaction bigger than application area
- Other effects:
- Total necrosis of the skin. That's why all animals were killed at 48 hours.
Any other information on results incl. tables
Results:
Observation time |
Erythema |
Edema |
1 hour |
4a/4a/4a |
4/4/3> |
24 hours |
4a/4a/4a |
3>/4/4 |
48 hours |
4n>/4n>/4n> |
n/n/n |
72 hours |
-/-/- |
-/-/- |
Mean (24, 48 and 72 h) |
4/4/4 |
-/-/- |
a : eschar on application area
> : Reaction bigger than application area
n: total necrosis of the skin
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (corrosive)
- Conclusions:
- Chlorodifluoroacetic acid is corrosive category 1 according to CLP 1272/2008/EC. However, the exposition time of 4 hours does not allow to differentiate between A, B or C categories.
- Executive summary:
In a GLP study, 0.5 ml of Chlorodifluoroacetic acid was applied on the back or flanks, of 3 New Zealand White rabbits (males), under semiocclusive conditions during 4 hours.
The highest score (4) was observed only after 1 hour of observation.
Regarding the total necrosis observed in all animals, bigger than the application area, animals were killed for human reason after 48 hours.
Based on these observation, Chlorodifluoroacetic acid can be classified as corrosive for the Skin, Category 1 according to CLP 1272/2008/EC. In absence of shorter exposition time it is not possible to apply a stronger classification based on this study alone.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.