2,3,4,5-tetrachlorobenzoylchloride

Repeated dose toxicity: oral

Administrative data

Endpoint:

repeated dose toxicity: oral

Remarks:

other: 84/449/EWG, B.7

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Data source

Reference

Reference Type:

other: Body responsible for the test

Title:

Unnamed

Year:

1991

Report date:

1991

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: 84/449/EWG, B.7

GLP compliance:

yes

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2,3,4,5-tetrachlorobenzoylchloride

EC Number:

406-760-3

EC Name:

2,3,4,5-tetrachlorobenzoylchloride

Cas Number:

42221-52-3

Molecular formula:

C7HCl5O

IUPAC Name:

2,3,4,5-tetrachlorobenzoyl chloride

Test material form:

solid: particulate/powder

Remarks:

migrated information: powder

Test animals

Species:

other: rat, Wistar SPF

Administration / exposure

Route of administration:

oral: unspecified

Vehicle:

other: Olivenöl

Details on oral exposure:

Method of administration:
Magensonde

Duration of treatment / exposure:

Test duration: 28 days

Frequency of treatment:

Dosing regime: 7 days/week
Male: 5 animals at 0 mg/kg bw/day
Male: 5 animals at 3 mg/kg bw/day
Male: 5 animals at 30 mg/kg bw/day
Male: 5 animals at 150 mg/kg bw/day
Female: 5 animals at 0 mg/kg bw/day
Female: 5 animals at 3 mg/kg bw/day
Female: 5 animals at 30 mg/kg bw/day
Female: 5 animals at 150 mg/kg bw/day

Results and discussion

Results of examinations

Details on results:

Clinical observations:
Es traten keine vorzeitigen Todesfälle auf. Das
Körpergewicht der Tiere der hohen Dosisgruppe war vermindert
(signifikant bei den Männchen).
"ENGLISH"
No premature mortalities occurred. The body weight of the
animals from the high-dose group was reduced (significantly
in the case of the male animals).
Laboratory findings:
Bei den Tieren der hohen Dosisgruppe wurden folgende
klinisch-chemische Veränderungen festgestellt: Abnahme der
Glucosewerte (Männchen), Anstieg von Serum Kreatinin,
Bilirubin, Triglyzeriden, alkalischer Phosphatase und
Abnahme der Chloridwerte für Männchen und Weibchen und ein
Anstieg der Alaninaminotransferase bei den Weibchen. Bei den
Tieren der Erholungsgruppe waren alle Werte mit Ausnahme der
Glucosewerte wieder unauffällig.
"ENGLISH"
The following clinico-chemical changes were established
among the animals from the high-dose group: reduction in the
glucose values (males), increase in serum creatine,
bilirubin, triglycerides, alkaline phosphatase and a
decrease in the chloride values for males and females and
an increase in the alanine aminotransferase among the
females. In the case of the animals from the recovery group,
with the exception of the glucose values, all of the values
were inconspicuous.
Effects in organs:
Die absoluten Organgewichte von Hirnanhangdrüse, Herz und
Milz und die relativen Organgewichte von Hirnanhangdrüse und
Leber waren bei den Weibchen signifikant vermindert; bei den
Männchen war das absolute Gehirngewicht signifikant
geringer.
Histologisch ergaben sich keine substanzbedingten
Veränderungen.
"ENGLISH"
The absolute organ weights of the pituitary gland, heart and spleen and the relative organ weights of the pituitary gland
and liver were significantly reduced among the females; in
the case of the male animals, the absolute brain weight was
significantly lower.
Histologically, there were no substance-related changes.

Effect levels

Dose descriptor:

NOEL

Effect level:

30 mg/kg bw/day (nominal)

Basis for effect level:

other: original NCD unit is mg/kg/day.

Target system / organ toxicity

Critical effects observed:

not specified

Applicant's summary and conclusion

Conclusions:

Classified as: Not classified