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Diss Factsheets
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EC number: 206-851-6 | CAS number: 383-63-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
A study was identified as the key study (Sire, 2007). In a local lymph node assay performed according to the OECD guideline No.429 and in compliance with the GLP, ethyl trifluoroacetate (purity 99.94%) in acetone/olive oil was administered to female CBA/J mice (4 animals/dose). The test item was non-irritant (ear thickness measurement) in the preliminary test, whatever the concentration. Therefore, the highest concentration retained for the main test was the maximal practicable concentration (100%), according to the criteria specified in the International Guidelines. For the main test the concentrations were 0, 5, 10, 25, 50 and 100% of the test item. The Lymph node proliferative responses were measured as described by Kimber and Dearman (1991). The positive control HCA (α-hexylcinnamaldehyde) at 25% presented a Stimulation Index (SI) of 5.24.Therefore, the positive control gave acceptable positive results and the study can be considered valid. No clinical signs and no mortality were observed during the study. Furthermore, no irritation of the skin was noted following the application of the test item. The LLNA gave negative results, as the SI is lower than 1 (SImax of 0.96 at 50% ethyl trifluoroacetate) in the animals treated whatever the concentration of the test item.
Under the test conditions, ethyl trifluoroacetate is not a dermal sensitizer in the murine Local Lymph Node Assay.
Migrated from Short description of key information:
Not sensitising: LLNA (SImax=0.96) (Key study, reliability Kr. 1, OECD 429)
Justification for selection of skin sensitisation endpoint:
Key study performed according to the OECD guideline No.429 and in compliance with the GLP,
Respiratory sensitisation
Endpoint conclusion
- Additional information:
No data
Migrated from Short description of key information:
No data
Justification for classification or non-classification
Harmonized classification:
No harmonized classification is available for human health according to the Regulation (EC) No. 1272/2008 including the ATP2.
Self-classification:
Based on the available data, ethyl trifluoroacetate is not classified for skin sensitisation according to the criteria of the Annex I of the Regulation (EC) No 1272/2008 (CLP) and to the criteria of the Annex VI of the Directive 67/548/EEC.
For the respiratory sensitisation, no data was available.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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