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EC number: 206-851-6 | CAS number: 383-63-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 1983-03-03 to 1983-03-25
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study performed similarly to OECD guideline 401 but without GLP compliance.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- Principles of method if other than guideline:
- not applicable
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Ethyl trifluoroacetate
- EC Number:
- 206-851-6
- EC Name:
- Ethyl trifluoroacetate
- Cas Number:
- 383-63-1
- Molecular formula:
- C4H5F3O2
- IUPAC Name:
- ethyl 2,2,2-trifluoroacetate
- Details on test material:
- - Name of test material (as cited in study report): Trifluoroacetate d'ethyle
- Physical state: clear liquid
- Stability under test conditions: assume to be stable (sponsor responsibility)
- Storage condition of test material: no data
- Other: density: 1.19
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: centre d'élevage d'IFFA CREDO (69210 St-Germain sur l'Arbresle, France)
- Age at study initiation: 6-7 weeks
- Weight at study initiation: males : 180-190 g - females: 150-160 g
- Fasting period before study: yes, no water 17 hours before the gavage. The animals can eat and drink 3 hours after the gavage.
- Housing: per group of 2 or 5 animals in plastic cages (37.5 x 23.5 x 16.0 cm) with sawdust litter
- Diet (e.g. ad libitum): Souriffarat diet, ad libitum
- Water (e.g. ad libitum): tap water, ad libitum
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 1.5 °C
- Humidity (%): 55 +/- 15%
- Air changes (per hr): 10
- Photoperiod (hrs dark / hrs light): no data
IN-LIFE DATES: From: To: no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Remarks:
- the test item is administered as supplied by the sponsor
- Details on oral exposure:
- VEHICLE
Not applicable, the test item is administered as supplied by the sponsor
MAXIMUM DOSE VOLUME APPLIED: 5010 mg/kg corresponded to 4.21 mL/kg (see details on Table 7.2.1/1)
DOSAGE PREPARATION (if unusual): not applicable
CLASS METHOD (if applicable)
Not applicable - Doses:
- preliminary test: 1011, 2511 and 5010 mg/kg
Main test: 0 and 5010 mg/kg bw - No. of animals per sex per dose:
- preliminary test: 2
main test: 5 - Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: clinical signs: 1h, 2h and 6h after the administration of the test item and then daily until the end of the test. weighing: day 1, 2, 4, 7 and 14 after the administration of the test item.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, macroscopic observations - Statistics:
- no data
Results and discussion
- Preliminary study:
- No mortality was observed at any tested doses. No further data.
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 010 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality was observed at the tested dose (5010 mg/kg bw).
- Clinical signs:
- other: weariness was observed in all animals (males and females) 2h after the gavage. This effect was observed during 24h in males and 72h in females.
- Gross pathology:
- no effects were observed.
- Other findings:
- no other findings
Any other information on results incl. tables
no other information.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the test conditions, since the LD50 is higher than 5010 mg/kg bw, Ethyl Trifluoroacetate is not classified for acute oral toxicity according to the Annex I of the CLP regulation 1272/2008 and the Annex VI of the Directive 67/548/EEC.
- Executive summary:
In an acute oral toxicity study performed similarly to the OECD guideline No. 401, groups of male and female Sprague-Dawley rats (2 for the preliminary test and 5 animals/sex/dose for the main test) were administered by gavage a single oral dose of undiluted Ethyl trifluoroacetate (97.3 %). In the preliminary test, 3 doses were tested: 1011, 2511 and 5010 mg/kg bw. As no mortality occurred, the highest dose of 5010 mg/kg bw was chosen for the main test. A control group consisted in 2 males and 2 females, treated with deionized water, was also tested during the main test.
Clinical signs and mortality were checked 1h, 2h and 6h after the administration of the test item and then daily until the end of the test (14 days). The body weight gain was measured at day 1, 2, 4, 7 and 14 after the administration of the test item. 14 days after the gavage with ethyl Trifluoroacetate, the animals were killed and necropsied for macroscopic observations.
Two hours after the administration of the test item at 5010 mg/kg bw (main test), weariness was observed in all animals (males and females). This effect was observed during 24h in males and 72h in females. No mortality was observed neither in the treated group nor in the control group. Macroscopic examination of the main organs of the animals revealed no apparent abnormalities.
Therefore the LD50 was determined to be higher than 5010 mg/kg bw.
Under the test conditions, Ethyl Trifluoroacetate is not classified for acute oral toxicity according to the Annex I of the Regulation (EC) 1272/2008 (CLP) and the Annex VI of the Directive 67/548/EEC.
This study is considered as acceptable and satisfies the requirement for acute oral toxicity endpoint.
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