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EC number: 233-038-3 | CAS number: 10025-73-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1983
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: reliable paper published in a peer-reviewed journal; however, some experimental details are lacking and thus results are considered reliable with restrictions.
Data source
Reference
- Reference Type:
- publication
- Title:
- Differential toxicity and clearance kinetics of chromium(III) or (VI) in mice
- Author:
- W.G.Bryson and C.M.Goodall
- Year:
- 1 983
- Bibliographic source:
- Carcinogenesis Vol.4 No. 12 pp.1535 - 1539, 1983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The acute toxicities of the chromium(III) nitrate, chloride and sulphate salts, chromium(VI) trioxide and potassium dichromate(VI) after i.p. injection were determined in NZC male mice according to Weil's method (Weil, C.S. (1952), Tables for convenient calculation of median-effective dose (LDa, or EDa) and instructions in their use, Biometrics, 8, 249-263.). The toxicities of chromium(III) trichloride and potassium dichromate(VI) were also re-determined in male and female (CxO) hybrid mice. The LD50 estimates (m3 = 3 day, md = distal or asymptotic, usually 10 day, estimates), and their confidence ranges, were calculated from Weil's tables, utilising at least 5 dose levels and 4 mice per level. Statistical comparisons were by Student's t-test.
- GLP compliance:
- no
- Remarks:
- pre-dates GLP requirement
- Limit test:
- no
Test material
- Reference substance name:
- Chromium trichloride
- EC Number:
- 233-038-3
- EC Name:
- Chromium trichloride
- Cas Number:
- 10025-73-7
- Molecular formula:
- Cl3Cr
- IUPAC Name:
- chromium trichloride
- Reference substance name:
- Chromium(III) chloride, hexahydrate (1:3:6)
- Cas Number:
- 10060-12-5
- Molecular formula:
- CrCl3.6H2O
- IUPAC Name:
- Chromium(III) chloride, hexahydrate (1:3:6)
- Reference substance name:
- chromium trichloride hexahydrate
- IUPAC Name:
- chromium trichloride hexahydrate
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- Chromium(III) trichloride (CrCl3.6HO) (AnalaR grade BDH) was dissolved in degassed distilled water and stood one week in a sealed flask to allow complete aquation (a slow process) to the hexaaquo chromium(III) ion, [Cr(H2O)6 ]3+.
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- mouse
- Strain:
- other: CxO F1 hybrids
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Mice were (CxO) F1 hybrids of both sexes from the original Cancer Research Department colonies. After weaning at age 4 weeks they were kept in polycarbonate cages (29 x 18 x 13 cm) with untreated wood shavings as litter in a room thermostatted at 22 °C and supplied with positive pressure, humidified and filtered ventilation. Mice were weighed and examined weekly. Treatments began at age 5 - 6 months.
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Details on exposure:
- Single injection, intraperitoneal applying weil's method.
- Doses:
- 7 dose levels were applied
- No. of animals per sex per dose:
- 4 males and 4 females per dose level
- Control animals:
- no
- Details on study design:
- In this study also potassium dichromate was applied accordingly to the same mice strain and thus results can be compared. However, exposure to potassim dichromate was at neutral pH (>6) to prevent corrosive symptoms (potassium dichromate is a strong oxidiser at low pH). Chromium trichloride solutions in contrast had a pH of less than 2.5.
- Statistics:
- The LD50 estimates (m3 = 3 day, md = distal or asymptotic, usually 10 day, estimates), and their confidence ranges, were calculated from Weil's tables, utilising at least 5 dose levels and 4 mice per level. Statistical comparisons were by Student's t-test.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 49.2 mg/kg bw
- Based on:
- element
- Remarks:
- chromium
- 95% CL:
- >= 35.3 - <= 68.6
- Remarks on result:
- other: concentrations were reported as µg Cr/g bw
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 42.2 mg/kg bw
- Based on:
- element
- Remarks:
- chromium
- 95% CL:
- >= 30.2 - <= 58.8
- Remarks on result:
- other: concentrations were reported as µg Cr/g bw
- Mortality:
- Chromium(VI) compounds had much higher acute toxicity, shown by the mean LD50 at 3 days (m3 of 15.4 µg/g, compared with 45.7 µg/g when chromium(III) salts were injected.
- Clinical signs:
- none reported
- Body weight:
- no details reported
- Gross pathology:
- no details reported
Applicant's summary and conclusion
- Conclusions:
- The intraperitoneal toxicity to mice was found being LD50 45.7 mg Cr/kg bw (i.e. 139 mg CrCl3/kg bw or 234 mg CrCl3.6H2O/kg bw respectively).
- Executive summary:
The intraperitoneal toxicity to mice was investigated and found being LD50 45.7 mg Cr/kg bw (i.e. 139 mg CrCl3/kg bw or 234 mg CrCl3.6H2O/kg bw respectively). Female mice seemed to be slightly more sensitive, although not statisitically significant as reported by the authors. Comparison to chromium(VI) compounds applied in the same test design showed that Cr(VI) compounds apparently have a higher toxicity, whereas other chromium(III) compounds tested (chromium trinitrate and chromium(III) sulphate) showed similar toxicities.
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