Adenosine 5'-(trihydrogen diphosphate), 2'-(dihydrogen phosphate), 5'→5'-ester with 3-(aminocarbonyl)-1-β-d-ribofuranosylpyridinium hydroxide, inner salt, disodium salt

Vapour pressure

Administrative data

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

June - October 2011

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Study conducted according to the respective OECD guideline and under GLP.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2011

Report date:

2011

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

GLP compliance:

yes

Type of method:

effusion method: by loss of weight or by trapping vaporisate

Remarks:

isothermal thermogravimetric effusion method

Test material

Test material information

Constituent 1

Reference substance name:

Adenosine 5'-(trihydrogen diphosphate), 2'-(dihydrogen phosphate), 5'→5'-ester with 3-(aminocarbonyl)-1-β-d-ribofuranosylpyridinium hydroxide, inner salt, disodium salt

EC Number:

246-129-8

EC Name:

Adenosine 5'-(trihydrogen diphosphate), 2'-(dihydrogen phosphate), 5'→5'-ester with 3-(aminocarbonyl)-1-β-d-ribofuranosylpyridinium hydroxide, inner salt, disodium salt

Cas Number:

24292-60-2

Molecular formula:

C21H28N7O17P3.2Na

IUPAC Name:

Adenosine 5'-(trihydrogen diphosphate), 2'-(dihydrogen phosphate), 5'→5'-ester with 3-(aminocarbonyl)-1-β-d-ribofuranosylpyridinium hydroxide, inner salt, disodium salt

Details on test material:

- Substance type: organic
- Physical state: white powder
- Storage condition of test material: in refrigerator (2-8°C)

Results and discussion

Vapour pressure

Vapour pressure 1

Temp.:

ca. 20 °C

Vapour pressure:

< 0.002 Pa

Vapour pressure 2

Temp.:

ca. 25 °C

Vapour pressure:

< 0.004 Pa

Applicant's summary and conclusion

Conclusions:

The isothermal TGA effusion method was applied for the determination of the vapour pressure of b-
NADP, Disodium salt. The vapour pressure of the test substance at 20°C and 25°C was: < 1.5 x 10-3 Pa and < 4.2 x 10-3 Pa respectively.

Executive summary:

The vapour pressure of the test substance (PT) was determined by the isothermal thermogravimetric effusion method (OECD 104). The method is validated in the range 10-8 - 103 Pa using a set of five reference substances with known vapour pressures. Approximately 4.81 and 5.26 mg of the test substance was applied to the surface of a roughened glass plate as a homogeneous layer using a suspension of the test substance in hexane. The plate was dried under nitrogen in the thermogravimetric analyzer (TGA). The weight loss of the test substance was measured continuously as a function of time. The vapour pressure is a function of the temperature and is specified in Pascal (Pa) or in mm Hg. The weight loss of the test substance at 110°C, 120°C, 130°C and 140°C was lower than the weight loss of hexachlorobenzene at the same temperatures. The vapour pressure of the test substance at 20°C and 25°C was: < 1.5 x 10-3 Pa and < 4.2 x 10-3 Pa respectively.