Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-076-7 | CAS number: 51-03-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1991
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- 2-(2-butoxyethoxy)ethyl 6-propylpiperonyl ether
- EC Number:
- 200-076-7
- EC Name:
- 2-(2-butoxyethoxy)ethyl 6-propylpiperonyl ether
- Cas Number:
- 51-03-6
- Molecular formula:
- C19H30O5
- IUPAC Name:
- 2-(2-butoxyethoxy)ethyl 6-propylpiperonyl ether
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Source : Buckshire Corp. Perkasie, PA 18944, USA.
Age/weight at study initiation : 200-293 g
Number of animals per group : Five rats per test group
Control animals : No
The animals were housed and maintained in accordance with standards set forth in the Guide for the care and use of laboratory animals. The rats were acclimated to the laboratory for at least 7 days prior to dosing. Animals were individually identified by ear punch. Each cage was identified with a cage card displaying the project number, sex, date dosed, and responsible technician's initials.
Husbandry Conditions
Temperature: 19 -25°C.
Relative Humidity: 40 -70%.
Light: 12hour light/dark cycle.
Diet: ad libitum. Based on our current knowledge, no contaminants are known to be in this diet or water which might be expected to interfere with the objectives of the study.
Caging: Stainless steel elevated wire mesh flooring, 1 rat/cage
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- 2.01, 3.01, 3.70, 5.00, 7.50 and 11.25 g/kg bw
- No. of animals per sex per dose:
- 50
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 5 630 mg/kg bw
- Clinical signs:
- other: Clinical signs of intoxication were yellow anogenital staining, ruffled fur, lethargy and sometimes dark nasal (and ocular) staining and ruffled skin.
- Gross pathology:
- Gross pathological examination of animals which died showed a dark liquid in the lower gastrointestinal tract. Mainly at the higher dosage groups additional changes like clear or dark muzzle staining, haemorrhagic lungs, yellow genital staining, pale liver and/or kidney and gas in the lower gastrointestinal tract were observed in one or the other case.
Any other information on results incl. tables
NOEL for clinical signs is 2.01 g/kg b.w.
Acute oral LD50:
male rats as 4.57 g/kg (3.65 – 5.73 g/kg)
female rats as 7.22 g/kg (4.94 – 10.55 g/kg)
rats (both sexes) as 5.63 g/kg ( 4.40 – 7.2 g/kg)
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test article, when administered as supplied to male albino rats, has an acute oral LD50 of 4.57g/Kg of active ingredent with 95% confidence limits from 3.65 to 5.73 g/Kg of active ingredient.
The test article, when administered as supplied to female albino rats, has an acute oral LD50 of 7.22 g/Kg of active ingredent with 95% confidence limits from 4.94 to 0.55 g/Kg of active ingredient.
The test article, when administered as supplied to male and female albin rats combined, has an acute oral LD50 of 5.63 g/Kg of active ingredent with 95% confidence limits from 4.40 to 7.20 g/Kg of activee ingredient.
The no effect level for clinical signs is 2.01 g/Kg.
Piperonyl ^Butoxide is of low acute oral toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.