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Diss Factsheets
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EC number: 232-007-1 | CAS number: 7783-54-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- short-term repeated dose toxicity: other route
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
Data source
Reference
- Reference Type:
- publication
- Title:
- Preliminary toxicological studies on nitrogen trifluoride
- Author:
- Torkelson, T. R., Oyen, F., Sadek, S. E. & Rowe, V. K.
- Year:
- 1 962
- Bibliographic source:
- Toxicological and applied pharmacology, 4, pp 770-781.
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Nitrogen trifluoride
- EC Number:
- 232-007-1
- EC Name:
- Nitrogen trifluoride
- Cas Number:
- 7783-54-2
- Molecular formula:
- F3N
- IUPAC Name:
- trifluoroamine
- Test material form:
- gas
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- male
Administration / exposure
- Route of administration:
- intraperitoneal
- Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- 7 injections, 2-6 d apart over a 23-d period
- Frequency of treatment:
- once daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
10 mL of undiluted NF3
- No. of animals per sex per dose:
- 4/gp
- Control animals:
- yes
Results and discussion
Results of examinations
- Clinical signs:
- no effects observed
- Description (incidence and severity):
- Rabbits gained weight and were normal in appearance during the entire experiment.
- Body weight and weight changes:
- no effects observed
- Description (incidence and severity):
- Rabbits gained weight and were normal in appearance during the entire experiment.
- Immunological findings:
- no effects observed
- Description (incidence and severity):
- Stained smears or peripheral blood and bone marrow did not reveal any abnormal changes.
- Gross pathological findings:
- effects observed, treatment-related
- Description (incidence and severity):
- At autopsy no evidence of local irritation was seen in the peritoneal cavity. The teeth were normal in appearance.
Enlargement of the spleen of the treated animals was the only abnormality seen during gross pathological examination. - Histopathological findings: non-neoplastic:
- effects observed, treatment-related
- Description (incidence and severity):
- Centriolobular vacuolisation of the cytoplasm were observed in the liver, with liver cells appearing larger than normal. Myocardial degeneration was seen in the hearts of the treated animals. The sinuses of the spleens were distended and RBC had infiltrated the pulp. There was also a moderate increase in the connective tissue of the spleen. Analysis of several wet tissues for total fluroride content indicated an increase in the fluoride content of the blood, bones and teeth and is evidenced that NF3 was in part metabolised.
Effect levels
- Dose descriptor:
- NOAEL
- Basis for effect level:
- other: increased wts of heart, liver, spleen with microscopic changes observed. Total fluoride content was increased in blood, bones and teeth
- Remarks on result:
- not determinable
- Remarks:
- no NOAEL identified
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
The effects observed acutely were not observed following repeated exposure, this may be due to the fact that MetHb is more difficult to produce in the rabbit than the rat (at least this is true for acetanilide and acetophenetidine).
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.