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EC number: 232-007-1 | CAS number: 7783-54-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
As NF3is a gas the oral and dermal route of exposure are not considered relevant.
Of the numerous inhalation experiments conducted with NF3only one experiment meets the requirements of REACh (Deichmann & Gerade) of a 4 hour exposure. The LC50value reported here was 2000 ppm (equivalent to 5920 mg/m3) in mice; however details regarding the design of this study are lacking, with only an LC50value reported.
In the Vernotet al(1973) study, the inhalatory toxicity of NF3was determined in a number of species including the rat and mouse. The design for this consisted of a single 1 hour exposure to rats and mice exposed whole body. The 1 hour LC50values reported in this study were 6700 ppm (2264 mg/m3) and 7500 ppm 2534 mg/m3) for rats and mice, respectively. The rat value has been directly cited by the ISO 10298 International standards document for the determination of a gas or gas mixture. The inclusion of the mouse value here is compare the value obtained with the rat and the Deichmann & Gerade study.
The data reported by Vernot et alconfirms that there is little in difference in terms of the acute toxicity of NF3to mice or rats following a 1 h, whole-body exposure.
Following time adjustment using Haber’s rule to a 4h LC50a value of 3350 ppm was derived for the rat (and 3750 ppm for the mouse). It is noted (by ISO 10298) that the use of Haber’s rule predicts a lower LC50value when extrapolating from 1h to a 4h LC50value. When comparing time adjusted 4h LC50valuevs.experimentally generated data for the mouse, the time adjusted value is almost 2-fold greater. However, as originally stated however, the data reported by Deichmann & Gerade is not open to scientific scrutiny as no experimental details have been found in the published literature. It is therefore deemed appropriate to use the time adjusted LC50value, which is viewed as a more conservative estimate of the toxicity. Furthermore, the rat LC50value provides further assurance as it is the lower of the two time adjusted values.
Justification for selection of acute toxicity – oral endpoint
As nitrogen trifluoride is a gas, the oral route of exposure is not relevant
Justification for selection of acute toxicity – inhalation endpoint
The only available data in the literature which complies with requirements of REACh
Justification for selection of acute toxicity – dermal endpoint
As nitrogen trifluoride is a gas, the dermal route of exposure is not relevant
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because a study on acute toxicity by the inhalation route is available
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Quality of whole database:
- n/a
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP and non-guideline compliant
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Study involved exposing several species of animal in NF3 for various times in order to determine LC50 values for 15, 30 and 60 mins
- GLP compliance:
- no
- Test type:
- fixed concentration procedure
- Limit test:
- no
- Species:
- other: rat ,mice, monkey, dog
- Strain:
- other: SD, ICR, rhesus, beagle
- Route of administration:
- inhalation: gas
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- Male SD and ICR mice were exposed (whole body) in a 30L bell jar chamber (10/gp of the same species). NF3 was introduced into the air stream prior to entry into a duplicate chamber which was used to establish contaminant concentrations. Air flow was fixed at 30 L/minute.
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- ca. 15 - ca. 60 min
- Concentrations:
- Refer to results section
- No. of animals per sex per dose:
- 10/gp
- Control animals:
- no
- Details on study design:
- Animals surviving the exposure were held up to 2 weeks to include delayed deaths.
- Statistics:
- LC50 calculations were made by computerised version of the probit method of Finney.
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- ca. 6 700 ppm
- 95% CL:
- ca. 6 130 - ca. 7 320
- Exp. duration:
- 60 min
- Remarks on result:
- other: rat
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- ca. 3 350 ppm
- Based on:
- other: time adjusted
- Exp. duration:
- 4 h
- Remarks on result:
- other: rat
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- ca. 7 500 ppm
- 95% CL:
- ca. 6 800 - ca. 8 280
- Exp. duration:
- 60 min
- Remarks on result:
- other: mouse
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- ca. 3 700 ppm
- Based on:
- other: time adjusted
- Exp. duration:
- 4 h
- Remarks on result:
- other: mouse
- Interpretation of results:
- Category 4 based on GHS criteria
Reference
Table 7.2.2/01-1: Mortality in rats and mice exposed to NF3 for 60 minutes
Concentration (ppm) |
Mortality |
|
Mean |
Range |
|
RAT |
||
4118 |
4018 – 4428 |
0/10 |
5117 |
5002 – 5298 |
1/10 |
6121 |
5986 – 6232 |
4/10 |
7190 |
7134 – 7257 |
5/10 |
8204 |
8036 – 8282 |
9/10 |
LC50: 6700 ppm (6130 – 7320) |
||
MOUSE |
||
4112 |
3854 - 4264 |
0/10 |
6469 |
6297 – 6560 |
3/10 |
7150 |
6888 – 7544 |
4/10 |
8200 |
8150 – 8250 |
6/10 |
12218 |
12136 – 12300 |
10/10 |
LC50: 7500 ppm (6800 – 8280) |
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 9 916 mg/m³ air
- Quality of whole database:
- The study is not GLP compliant. From the 1h LC50 value determined in this study, the value has been time adjusted using Haber's rule to extrapolate to a 4h exposure
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- the study does not need to be conducted because inhalation of the substance is likely
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Quality of whole database:
- n/a
Additional information
Justification for classification or non-classification
Acute oral toxicity:waiver requested as NF3 is a gas the oral route of exposure is not relevant.
Acute toxicity inhalation:The test material should be classified as ‘Acute Tox 4’ and the hazard statement ‘H332: Harmful if inhaled' should be applied according to the harmonised classification in Regulation 1272/2008.
Acute toxicity dermal:waiver requested as NF3 is a gas the dermal route of exposure is not relevant
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