Registration Dossier
Registration Dossier
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EC number: 255-485-3 | CAS number: 41669-30-1
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
Readily biodegradable: 68.1 - 71.7% (CO2 evolution) after 29 d (OECD 301B)
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
Since no studies investigating the ready biodegradability of isooctadecyl isooctadecanoate (CAS 41669-30-1) are available for this endpoint, in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5 a read-across to the structurally related source substance 2-octyldodecyl isooctadecanoate (CAS 93803-87-3) was conducted. The read-across substance is representative to evaluate the biodegradation of isooctadecyl isooctadecanoate. 2-octyldodecyl isooctadecanoate is characterized by the same fatty acid chain length (isooctadecanoic acid) and a similar branched alcohol component (2-octyldodecanol compared to isohexadecanol/isooctadecanol for the target substance). This read-across is justified in detail in the overall summary (IUCLID Section 6.1) and within the analogue justification in IUCLID Section 13.
The study with the source substance 2-octyldodecyl isooctadecanoate was performed according to OECD 301B under aerobic conditions using domestic activated sludge as inoculum (Desmares-Koopmans, 1998). A test substance concentration of approx. 14.5 mg/L was degraded to an extent of 68.1 - 71.7% after 29 d. Since 2-octyldodecyl isooctadecanoate is a UVCB substance and consists of structurally similar constituents with [e.g. different chain-lengths, degree and/or site of branching or stereo-isomers], sequential (instead of concurrent) biodegradation of the individual structures can take place, but all can be considered as readily biodegradable. Thus, referring to Annex I of the OECD Guideline for Testing of Chemicals ‘Revised introduction to the OECD guidelines for testing of chemicals, section 3’ (OECD, March 2006), the 10-day window should not be considered for this UVCB substance and due to a degradation of >60% within 28 days the substance can be regarded as readily biodegradable. Moreover, the read-across substance is assumed not to be inhibitory to activated sludge microorganisms based on a biodegradation of > 25% in the toxicity control after 14 d.
Based on the results from one structurally related read-across substance (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) it can be concluded that the target substance isooctadecyl isooctadecanoate is readily biodegradable according to the OECD criteria.
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