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EC number: 203-223-3 | CAS number: 104-65-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer reviewed journal
Data source
Reference
- Reference Type:
- publication
- Title:
- Fragrance material review on Benzyl formate
- Author:
- D. McGinty; C.S. Letizia; A.M. Api
- Year:
- 2 012
- Bibliographic source:
- Food and Chemical Toxicology, 50 (2012) S402-S406.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- To evaluate the eye irritation potential of benzyl formate on SPF albino rabbits
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Benzyl formate
- Cas Number:
- 104-57-4
- Molecular formula:
- C8H8O2
- IUPAC Name:
- Benzyl formate
- Details on test material:
- IUPAC: Benzyl formate
Molecular formula :C8H8O2
Molecular weight :136.15 g/mol
Substance type:organic
InChI:1S/C8H8O2/c9-7-10-6-8-4-2-1-3-5-8/h1-5,7H,6H2
Smiles :c1(ccccc1)COC=O
Constituent 1
- Specific details on test material used for the study:
- IUPAC: Benzyl formate
Molecular formula :C8H8O2
Molecular weight :136.15 g/mol
Substance type:organic
InChI:1S/C8H8O2/c9-7-10-6-8-4-2-1-3-5-8/h1-5,7H,6H2
Smiles :c1(ccccc1)COC=O
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: SPF albino rabbits
- Details on test animals or tissues and environmental conditions:
- 4 animals were used
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: The untreated eye of each animal served as a control.
- Amount / concentration applied:
- 0.1 ml
- Duration of treatment / exposure:
- No data available
- Observation period (in vivo):
- 1, 48, 72 h and 7 days
- Details on study design:
- Application of fluorescein was used for the confirmation of findings.
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 7 d
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- ocular reactions were observed by 24 , 48 , 72 hrs after installation of test substance, which was reversible by day 7
- Other effects:
- At 24 h after dosing, corneal opacity was scattered or diffuse on more than one quarter but less than one half of the cornea.
The conjunctiva were diffuse, crimson red with individual vessels not easily discernible, swelling was noted as well as an abnormal
discharge.
At 48 h after dosing, the scattered or diffuse area of opacity was noted on one quarter or less of the cornea, even after instillation of fluorescein
Applicant's summary and conclusion
- Interpretation of results:
- other: Not eye irritant
- Conclusions:
- Benzyl formate when applied on the eye of SPF albino rabbits and observed for 7 days gave ocular reactions which were cleared by day 7. Hence , Benzyl formate is considered to be non eye irritant.
- Executive summary:
Benzyl formate (undiluted) was evaluated for eye irritation in four female SPF alibino rabbits. A dose volume of 0.1 ml was instilled into one eye. The untreated eye of each animal served as a control. Observations were made at 1, 48, 72 h and 7 days after treatment. At 24 h after dosing, corneal opacity was scattered or diffuse on more than one quarter but less than one half of the cornea. Application of fluorescein confirmed this finding. The conjunctivawere diffuse, crimson red with individual vessels not easily discernible, swelling was noted as well as an abnormal discharge. At 48 h after dosing, the scattered or diffuse area of opacity was still noted on one quarter or less of the cornea, even after instillation of fluorescein. The conjunctiva was diffusely red; the individual vessels were not easily discernible and abnormal swelling was present. At 72 h after dosing, the conjunctival vessels were injected and following the instillation of fluorescein a scattered or diffuse area of opacity on one quarter or less of the cornea was noted. By 7 days after dosing the animals were free of any signs of eye irritation
Benzyl formate when applied on the eye of SPF albino rabbits and observed for 7 days gave ocular reactions which were cleared by day 7. Hence , Benzyl formate is considered to be non eye irritant.
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