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Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from peer-reviewed journal

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Fragrance material review on Cinnamyl formate
Author:
S.P. Bhatia, G.A. Wellington , J. Cocchiara , J. Lalko , C.S. Letizia , A.M. Api
Year:
2007
Bibliographic source:
Food and Chemical Toxicology 45 (2007) S70–S73
Reference Type:
publication
Title:
The FEMA GRAS assessment of cinnamyl derivatives used as flavor ingredients
Author:
Timothy B. Adamsa, Samuel M. Cohenb, John Daulle, Victor J. Ferond, Jay I. Goodmane, Lawrence J. Marnettf, Ian C. Munrog, Philip S. Portogheseh, Robert L. Smithi, William J. WaddeW, Bernard M. Wagnerk
Year:
2004
Bibliographic source:
Food and Chemical Toxicology 42 (2004) 157-185
Reference Type:
publication
Title:
Monographs on Fragrance Raw Materials: Cinnamyl formate
Author:
D. L. J. Opdyke
Year:
1976
Bibliographic source:
Food and Cosmetics Toxicology,Volume 14, Supplement, Pages 659-893 (1976)
Reference Type:
publication
Title:
Acute oral toxicity study of Cinnamyl formate (104-65-4) in Rat
Author:
U.S. National Library of Medicine
Year:
2017
Bibliographic source:
Chemidplus Database,U.S. National Library of Medicine ,2017
Reference Type:
publication
Title:
A toxicologic and dermatologic assessment of related esters and alcohols of cinnamic acid and cinnamyl alcohol when used as fragrance ingredients
Author:
D. Belsito, D. Bickers , M. Bruze , P. Calow , H. Greim ,J.M. Hanifin, A.E. Rogers , J.H. Saurat, I.G. Sipesi, H. Tagami
Year:
2007
Bibliographic source:
Food and Chemical Toxicology, 45, (2007) S1–S23

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: As mentioned below
Principles of method if other than guideline:
Acute Oral toxicity test was carried out to study the effects of Cinnamyl formate (104-65-4) on rats.
GLP compliance:
not specified
Test type:
other: No data available
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Cinnamyl formate
EC Number:
203-223-3
EC Name:
Cinnamyl formate
Cas Number:
104-65-4
Molecular formula:
C10H10O2
IUPAC Name:
cinnamyl formate
Details on test material:
- Name of test material (IUPAC name): Cinnamyl formate
- Common name: 3-Phenylallyl formate
- Molecular formula: C10H10O2
- Molecular weight: 162.187 g/mol
- Smiles notation: c1(\C=C\COC=O)ccccc1
- InChl: 1S/C10H10O2/c11-9-12-8-4-7-10-5-2-1-3-6-10/h1-7,9H,8H2/b7-4+
- Substance type: Organic
Specific details on test material used for the study:
- Name of test material (as cited in study report):Cinnamyl formate
- Molecular formula :C10H10O2
- Molecular weight :162.187 g/mol
- Substance type:Organic
- Physical state:Colorless to slightly yellow liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data available

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
No data available
Doses:
2000, 2500, 3200, 4000 and 5000 mg/kg/bodyweight
No. of animals per sex per dose:
Total: 50 animals
2000 mg/kg/bw = 10 animals
2500 mg/kg/bw =10 animals
3200 mg/kg/bw =10 animals
4000 mg/kg/bw =10 animals
5000 mg/kg/bw =10 animals
Control animals:
not specified
Details on study design:
Details on study design
- Duration of observation period following administration: 7 days
- Frequency of observations and weighing: No data available
- Necropsy of survivors performed: No data available
- Other examinations performed: Clinical signs
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
2 900 mg/kg bw
Based on:
test mat.
95% CL:
> 2 380 - < 3 540
Remarks on result:
other: 50% mortality was observed
Mortality:
At 2000 mg/kg bw - 1 rat died.
At 2500mg/kg bw - 4 rats died.
At 3200 mg/kg bw - 7 rats died.
At 4000 mg/kg bw - 9 rats died.
At 5000 mg/kg bw - 9 rats died.
Clinical signs:
other: Clinical signs like ataxia and mucoid enteritis were observed
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
The lethal concentration (LD50) value for acute oral toxicity test was considered to be 2900 mg/kg bw(95% C.I. 2380–3540 mg/kg) ,when 50 rats were treated with Cinnamyl formate (104-65-4) orally.
Executive summary:

Acute Oral Toxicity study was performed in 50 rats using test material Cinnamyl formate (104-65-4). 50% Mortality was observed at dose 2900 mg/kg bw. A majority of the deaths occurred between days 1 and 2.Clinical signs like ataxia and mucoid enteritis were observed. Hence,LD50 value was considered to be 2900 mg/kg bw(95% C.I. 2380–3540 mg/kg),when rats were treated with Cinnamyl formate (104-65-4)orally.