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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from peer reviewed journals .

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Fragrance raw material monograph of cinnamyl formate
Author:
D. L. J. Opdyke
Year:
1972
Bibliographic source:
food and chemical toxicology 1972
Reference Type:
publication
Title:
A toxicologic and dermatologic assessment of related esters and alcohols of cinnamic acid and cinnamyl alcohol when used as fragrance ingredients
Author:
D. Belsito, D. Bickers , M. Bruze , P. Calow , H. Greim ,J.M. Hanifin, A.E. Rogers , J.H. Saurat, I.G. Sipesi, H. Tagami
Year:
2007
Bibliographic source:
Food and Chemical Toxicology, 45, (2007) S1–S23

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
To evaluate the skin irritation potential of Cinnamyl formate on human male volunteers
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Cinnamyl formate
EC Number:
203-223-3
EC Name:
Cinnamyl formate
Cas Number:
104-65-4
Molecular formula:
C10H10O2
IUPAC Name:
cinnamyl formate
Details on test material:
- Name of test material (IUPAC name): Cinnamyl formate
- Common name: 3-Phenylallyl formate
- Molecular formula: C10H10O2
- Molecular weight: 162.187 g/mol
- Smiles notation: c1(\C=C\COC=O)ccccc1
- InChl: 1S/C10H10O2/c11-9-12-8-4-7-10-5-2-1-3-6-10/h1-7,9H,8H2/b7-4+
- Substance type: Organic
-physical state- colourless to yellowish liquid
Specific details on test material used for the study:
- Name of test material (IUPAC name): Cinnamyl formate
- Common name: 3-Phenylallyl formate
- Molecular formula: C10H10O2
- Molecular weight: 162.187 g/mol
- Smiles notation: c1(\C=C\COC=O)ccccc1
- InChl: 1S/C10H10O2/c11-9-12-8-4-7-10-5-2-1-3-6-10/h1-7,9H,8H2/b7-4+
- Substance type: Organic
-physical state- colourless to yellowish liquid

Test animals

Species:
other: human
Strain:
not specified
Details on test animals or test system and environmental conditions:
No data available

Test system

Type of coverage:
occlusive
Preparation of test site:
not specified
Vehicle:
other: petroletum
Controls:
not specified
Amount / concentration applied:
4%
Duration of treatment / exposure:
48hrs
Observation period:
48hrs
Number of animals:
5 male volunteers
Details on study design:
no data available

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
48 h
Reversibility:
not specified
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
No skin reaction were observed

Applicant's summary and conclusion

Interpretation of results:
other: not irritant
Conclusions:
Cinnamyl formate when applied on 5 male volunteers gave no skin reaction. Cinnamyl formate was considered to be not irritating to human skin.
Executive summary:

Cinnamyl formate was used as a test material for maximization pre-test to evaluate it’s skin irritation potential on 5 male volunteers .

The test material was used in the concentration of 4% in petrolatum ,

No skin reactions were observed.Cinnamyl formate was considered to be not irritating to human skin.