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EC number: 207-074-5 | CAS number: 431-47-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- data is from NTRL reports
Data source
Reference
- Reference Type:
- secondary source
- Title:
- INITIAL SUBMISSION: LOCAL TOLERANCE TEST IN RABBITS-CUTANEOUS PRIMARY IRRITATION –OCCULAR IRRITATION OF METHYL TRIFLUROACETATE IN RABBITS WITH COVER LITTER DATED 101692
- Author:
- NTRL reports
- Year:
- 1 992
- Bibliographic source:
- OTS0571344, NTRL report, last updated 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Principles of method if other than guideline:
- To assess the dermal irritation potential of methyl trifluoroacetate in rabbits according to OECD 404 Guidelines
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Methyl trifluoroacetate
- EC Number:
- 207-074-5
- EC Name:
- Methyl trifluoroacetate
- Cas Number:
- 431-47-0
- Molecular formula:
- C3H3F3O2
- IUPAC Name:
- methyl 2,2,2-trifluoroacetate
- Test material form:
- liquid
- Details on test material:
- - Name of the test chemical: methyl trifluoroacetate
- Molecular formula: C3H3F3O2
- Molecular weight: 128.05 g/mol
- Smiles notation: O=C(OC)C(F)(F)F
- InChl: 1S/C3H3F3O2/c1-8-2(7)3(4,5)6/h1H3
- Substance type: Organic
- Physical state: Liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of the test chemical: methyl trifluoroacetate
- Molecular formula: C3H3F3O2
- Molecular weight: 128.05 g/mol
- Smiles notation: O=C(OC)C(F)(F)F
- InChl: 1S/C3H3F3O2/c1-8-2(7)3(4,5)6/h1H3
- Substance type: Organic
- Physical state: Liquid
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- sex: Male
- Source: Charles river
- Age at study initiation: no data
- Weight at study initiation: 2.5 kg (200g)
- Fasting period before study: no data
- Housing: The rabbits were kept in individual polystyrene cages, measuring 540×360×315mm with a perforated polystyrene flour in ventilated and air conditioner room.
- Diet (e.g. ad libitum): 150gm of complete maintenance food (granules Lapin Entration “112” UAR, 91360 – Villemoisson/Drge) is provided per rabbit per day.
- Water: ad libitum (softened and filtered water-15 µ)
- Acclimation period: 8 days
Rabbits were vaccinated against Myxomatosis (Lyomyxovax, institut Merleux)
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20°C ± 3
- Humidity (%): 30 to 70 %
- Air changes (per hr): 12 to 14 times per hours (pre-filtered air: 5- 10 µ)
- Photoperiod (hrs dark / hrs light): artificial lighting for 12 hrs (7.30am to 7.30pm)
IN-LIFE DATES: From: To: No data available
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 0.5 ml
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 24,48, 72 hours.The observation period may be extended to 7 or 14 days
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: whole clipped surface (back 14cm×14cm)
- % coverage:6 square centimeter area
- Type of wrap if used: bandage
REMOVAL OF TEST SUBSTANCE
- Washing (if done): If necessary the excess of the test substance which has not penetrated, the gauze pad moisten with deionized water (or non-irritant solvent)
- Time after start of exposure: No data available
SCORING SYSTEM: The mean values for erythema and edema were calculated for 6 rabbits examined at 1,24,48 and 72 hours after removal of the semi occlusive patches.
The cutaneous reactions were scored according to the following scale:
Erythema or Eschar formation:
no erythema =0
very slight erythema(barely perceptible) = 1
well defined erythema = 2
moderate to severe erythema = 3
severe erythema [beet redness] to slight eschar formation [injuries in depth] = 4
Edema formation:
No edema formation = 0
very slight edema(barely perceptible) = 1
slight edema [edges well defined by definte raising] = 2
moderate edema [edges raised approx 1mm] = 3
severe edema [raised more than 1mm and extending the area of exposure] = 4
Results and discussion
In vitro
- Other effects / acceptance of results:
- no data available
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 1 hr
- Score:
- 0.5
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24 hr
- Score:
- 0.17
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 48 and 72hr
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 1 hr
- Score:
- 0.17
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- The mean score for erythema and edema formation after 72 hours was 0.06 and 0.00 respectively
Any other information on results incl. tables
Table 1: Evaluation of cutaneous irritation potential after removal of patches
Rabbit number |
1263 |
1264 |
1265 |
1266 |
1267 |
1268 |
Total |
Mean |
|
|
Erythema
|
1 hour |
1 |
1 |
0 |
0 |
0 |
0 |
3 |
0.50 |
|
24 hours |
0 |
1 |
0 |
0 |
0 |
0 |
1 |
0.17 |
||
48 hours |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
||
72 hours |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
||
|
Erythema mean = 24+48+72 hours |
0.06 |
Rabbit number |
1263 |
1264 |
1265 |
1266 |
1267 |
1268 |
Total |
Mean |
|
|
Edema
|
1 hour |
0 |
1 |
0 |
0 |
0 |
0 |
1 |
0.17 |
|
24 hours |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
||
48 hours |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
||
72 hours |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
||
|
Edema mean = 24+48+72 hours |
0.00 |
Applicant's summary and conclusion
- Interpretation of results:
- other: not irritating
- Conclusions:
- The mean score for erythema and edema formation after 72 hours was 0.06 and 0.00 respectively.
Based on the scores, methyl trifluoroacetate can be considered not irritating to rabbit skin. - Executive summary:
The dermal irritation potential of methyl trifluoroacetate was assessed in rabbits. The study was performed according to OECD 404 Guidelines. Six male albino New Zealand rabbits were used for the study. The six rabbits are carefully clipped on the back and on the flanks with a fine toothed electronic clipper (Asaculap – type V 42 947), to bare a surface 14cm×14cm (cutting height: 1/20thmm). The skin must be perfectly clean shaven often clipping. 0.5 ml of the undiluted sterile test substance was applied with a sterile polypropylene syringe(Becton Dickson) of 2 ml, on a Codex hydrophilic eight layer gauze pad, about 2.5 square cms. The test substance and the gauze pad are held in contact with the skin using a semi- occlusive patch: 10 cm wide adhesive perforation tape applied on a crimped gauze covering the whole clipped surface and wrapped around the animal. The test substance is kept in contact with the skin for 4 hours and the animals are retained in plastic restrainers. After 4 hours the patches were removed and the excess material was wiped with a gauze pad moistened with deionized water. The animals were observed for signs of irritation (erythema and edema formation) 1, 24, 48 and 72 hours after patch removal. The observation may be extended to 7 or 14 days to determine the corrosive nature of the test chemical.
The mean score for erythema and edema formation after 72 hours was 0.06 and 0.00 respectively.
Based on the scores, methyl trifluoroacetate can be considered not irritating to rabbit skin.
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