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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin sensitisation

Currently viewing:

Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data from secondary source.

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
Skin sensitization study of Ethyl 3-ethoxypropionate was performed in guinea pig.
Author:
IFA GESTIS
Year:
2017
Bibliographic source:
Institut für Arbeitsschutz der Deutschen Gesetzlichen Unfallversicherung (IFA) GESTIS-database on hazardous substances, 2017
Reference Type:
secondary source
Title:
IUCLID Dataset - Ethyl 3-Ethoxypropionate
Author:
European Chemicals Bureau (ECB)
Year:
2000
Bibliographic source:
IUCLID Dataset - European Chemicals Bureau (ECB), 2000

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
other: As mentioned below
Principles of method if other than guideline:
Skin sensitization study of Ethyl 3-ethoxypropionate was performed in guinea pig by using Guinea pig maximisation test
GLP compliance:
not specified
Type of study:
Freund's complete adjuvant test
Justification for non-LLNA method:
not specified

Test material

Constituent 1
Reference substance name:
Ethyl 3-ethoxypropionate
Cas Number:
763-69-9
Molecular formula:
C7H14O3
IUPAC Name:
Ethyl 3-ethoxypropionate
Test material form:
liquid
Details on test material:
- Name of test material (as cited in study report): Ethyl 3-ethoxypropionate
- Molecular formula : C7H14O3
- Molecular weight :146.19g/mol
- Substance type: organic
- Physical state: liquid
- Purity: No data available
- Impurities (identity and concentrations): No data available
Specific details on test material used for the study:
- Name of test material (as cited in study report): Ethyl 3-ethoxypropionate
- Molecular formula : C7H14O3
- Molecular weight :146.19g/mol
- Substance type: organic
- Physical state: liquid
- Purity: No data available
- Impurities (identity and concentrations): No data available

In vivo test system

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
No data available

Study design: in vivo (non-LLNA)

No. of animals per dose:
10
Details on study design:
No data available
Challenge controls:
No data available
Positive control substance(s):
not specified

Study design: in vivo (LLNA)

Statistics:
No data available

Results and discussion

Positive control results:
No data available

In vivo (non-LLNA)

Results
Reading:
1st reading
Group:
test chemical
Dose level:
No data available
No. with + reactions:
0
Total no. in group:
10
Clinical observations:
no indication of skin sensitization after the challenge
Remarks on result:
no indication of skin sensitisation

Applicant's summary and conclusion

Interpretation of results:
other: Not Sensitizing
Conclusions:
The skin sensitization study of Ethyl 3-ethoxypropionate (763-69-9) was performed in Guinea pig was considered to be not skin sensitizing.

Executive summary:

The skin sensitization study of Ethyl 3-ethoxypropionate (763-69-9) was performed by Freund’s complete adjuvant testin 10guinea pigs.No skin sensitization reaction was noted.Hence it is considered that Ethyl 3-ethoxypropionate (763-69-9) was not skin sensitizing in guinea pig by Freund’s complete adjuvant test.