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Diss Factsheets
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EC number: 201-074-9 | CAS number: 77-99-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_ecotoxicological-information.png)
Endpoint summary
Administrative data
Description of key information
Additional information
Toxicity to fish:
Short-term toxicity to fish:
The acute toxicity of trimethylolpropane to the marine bleak (Alburnus alburnus) was determined in a static test with brackish water (7‰ salinity, pH 7.8) and with an exposure duration of 96 h. Six different concentrations, not further specified, were tested.Analytical monitoring was not performed. The 96-h LC50 was determined to be greater than 1000 mg/L as reported by Bengtsson and > 10,000 mg/L as reported by Linden (based on nominal concentrations).
The study satisfies the guideline requirements for an acute toxicity study with fish.
Reference: Bengtsson & Tarkpea, 1983, Linden et al., 1979
One of the supporting studies was performed with the freshwater species Oryzias latipes and resulted in the same endpoint: 96-h LC50 > 1000 mg/L. Reference: EA Japan /SIDS, <=1994 (Reliability 2).
Since the publications by Bengtsson & Tarkpea and Linden et al. are more detailed than the data in the SIDS on the study from EA Japan, they were chosen as key study.
Long-term toxicity to fish:
Due to the very low toxicity of trimethylolpropane to fish and a low potential to bioaccumulate in fish, a long-term toxicity test on fish is not needed.
Toxicity to aquatic invertebrates:
Short-term toxicity to aquatic invertebrates:
The 48-hr-acute toxicity of trimethylolpropane to Daphnia magna was studied under static conditions. Daphnids were exposed to the substance at nominal concentrations of 5,000; 7,500; 10,000; 15,000, 20,000, 25,000; 40,0000 mg/L. Immobilization was observed at 24 and 48h. The 48-hour EC50 was 13,000 mg/L (based on nominal concentrations). This study is classified as acceptable and satisfies the guideline requirements for an acute toxicity study with freshwater invertebrates.
Reference: Walton, J.R. and, E.M., 1980
Long-term toxicity to aquatic invertebrates:
A static 21-d test was performed with trimethylolpropane on Daphnia magna by following an OECD Guideline.
A NOEC > 1000 mg/L was determined.
Being performed by EA Japan according to a OECD-Guideline, the study is considered to be acceptable.
Reference: EA Japan / SIDS, <=1994
Toxicity to algae:
The toxicity of trimethylopropane on the green algae Pseudokirchneriella subcapitata (reported as Selenastrum carpicornutum) was tested according to an OECD guideline. The 72-h EbC50 was determined to be greater than 1000 mg/L (based on nominal concentrations).
Being performed by EA Japan according to a OECD-Guideline, the study is considered to be acceptable.
Reference: EA Japan/SIDS, <=1994
Toxicity to microorganisms (activated sludge):
The respiration inhibition of activated sludge from predominantly domestic sewage treatment plant by trimethylolpropane was determined according to the EU Guideline C.11 with an incubation time of 3 hours. The concentrations tested were 10, 100 and 1000 mg/L. EC50 of the reference substance 3,5 - dichlorophenol was 9.2 mg/L ( 95% C.I. 3 - 24 mg/L). The respiration rates of the 2 controls differed less than 15% from each other.
The EC50 and the EC10 for trimethylolpropane were determined to be > 1000 mg/L.
The validity criteria of the guideline are fulfilled.
Reference: Neuhahn, 2010
Toxicity to other aquatic organisms (fish larvae):
The acute toxicity was tested in a static test on larvae of Petromyzon marinus. A 24h-LC0 was determined to be > 5 mg/L.
The study does not meet important criteria of today's standards and is therefore notc onsidered to be reliable.
Reference: Applegate, 1957
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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