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Toxicological information

Repeated dose toxicity: dermal

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Administrative data

Endpoint:
sub-chronic toxicity: dermal
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: insufficient reporting for assessment

Data source

Reference
Reference Type:
publication
Title:
Maximum permissible concentration of trimethylolpropane (etriol) in factory air
Author:
Stankevich, V.V.:
Year:
1967
Bibliographic source:
Hygiene and Sanitation 32(5), 288-291

Materials and methods

Principles of method if other than guideline:
daily application to the skin of rabbits for 4 hours (no further data) or the tail was immersed in an aquous solution daily for 4 hours .
observation for effects
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
no further data

Test animals

Species:
other: rabbits and mice
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
no data

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Details on exposure:
Route of Administration: dermal exposure time: daily 4 hours
Analytical verification of doses or concentrations:
not specified
Details on analytical verification of doses or concentrations:
no data
Duration of treatment / exposure:
3 months
Frequency of treatment:
daily 4 hours
Doses / concentrations
Remarks:
Doses / Concentrations:
0.5 ml of 50 % aqueous solution/animal/d
Basis:

No. of animals per sex per dose:
no data for rabbits and no data for mice
Control animals:
other: no data specified
Details on study design:
Post-exposure period: no data
Positive control:
no data

Examinations

Observations and examinations performed and frequency:
reactions on skin and behavior
Sacrifice and pathology:
no data
Other examinations:
no data
Statistics:
no data

Results and discussion

Results of examinations

Clinical signs:
no effects observed
Dermal irritation:
no effects observed
Mortality:
no mortality observed
Body weight and weight changes:
no effects observed
Food efficiency:
not specified
Water consumption and compound intake (if drinking water study):
not specified
Ophthalmological findings:
not specified
Clinical biochemistry findings:
not specified
Urinalysis findings:
not specified
Behaviour (functional findings):
not specified
Gross pathological findings:
not specified
Histopathological findings: non-neoplastic:
not specified
Histopathological findings: neoplastic:
not specified
Details on results:
RS-Freetext: no visible effect at the site of application, no change in the general condition of the animals

Effect levels

Dose descriptor:
conc. level: 50% aquous solution
Effect level:
50 other: % aquous solution
Sex:
not specified
Basis for effect level:
other: no effects were observed

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

RS-Freetext:
no visible effect at the site of application, no change in
the general condition of the animals

Applicant's summary and conclusion