Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 485-290-0 | CAS number: 3021-02-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 431
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- -
- EC Number:
- 485-290-0
- EC Name:
- -
- Cas Number:
- 3021-02-1
- Molecular formula:
- C2H8N10
- IUPAC Name:
- 5-(1H-1,2,3,4-tetrazol-5-yl)-1H-1,2,3,4-tetrazole diamine
- Reference substance name:
- 5,5'-Bi-1H-tetrazole diammonium salt
- IUPAC Name:
- 5,5'-Bi-1H-tetrazole diammonium salt
Constituent 1
Constituent 2
Test system
- Type of coverage:
- open
- Preparation of test site:
- other: human skin modell
- Vehicle:
- water
Results and discussion
In vitro
Results
- Irritation / corrosion parameter:
- other: other: corrosion index
- Value:
- > 105
- Remarks on result:
- other:
- Remarks:
- Basis: other: photometric absorption. Time point: 1 h. Max. score: 15.0. Reversibility: no data. Remarks: if the absorption exceeds 15 %, the substance can be considered to be not corrosive. (migrated information)
Any other information on results incl. tables
All validity criteria were fulfilled; the positive control
was clearly corrosive and the OD of the negative control lay
well above 0.8.
After treatment with the test item, the relative absorbance
values were decreased to 90.4 percent after 3 min. treat-
ment. This value is well above the threshold for corrosi-
vity (50 percent). After 1 hour treatment relative absor-
bance values were increased to 105.1 percent.
This value is well above the threshold for corrosi-
vity (50 percent). After 1 hour treatment relative absor-
bance values were increased to 105.1 percent. This value
is far above the threshold for corrosivity (15 percent).
Therefore, the test item is considered as "not corrosive".
The values of the negative control were well above the
required acceptability criterion of a mean OD > 0.8 for both
treatment interval thus showing the quality of the tissues.
The value of the positive control induced a decrease in the
relative absorbance as compared to the negative control to
20.5 % for the 3 minutes treatment interval and 13.3 % for
the 1 hour treatment interval thus ensuring the validity of
the test system.
For these reasons, the result of the test is considered
valid.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- After treatment with the test item, the relative absorbance values were decreased to 90.4% after 3 min. treatment. This value is well above the threshold for corrosivity (50%). After 1 hour treatment relative absorbance values were increased to 105.1%. This value is far above the threshold for corrosivity (15%).
Therefore, the test item is considered as "not corrosive".
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)