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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2001

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
GLP compliance:
yes
Limit test:
yes

Test material

Constituent 1
Reference substance name:
Red 0106-PP1
IUPAC Name:
Red 0106-PP1

Test animals

Species:
other: HanBrl: Wist (SPF) rats

Administration / exposure

Type of coverage:
semiocclusive
Vehicle:
other: Polyethylene glycol 300 (PEG300)
Duration of exposure:
24 h

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Mortality:
No deaths occurred during the study.
Clinical signs:
No clinical signs were noted.



Body weight:
The body weight of the animals was within the range commonly recorded for animals of this strain and age.

Gross pathology:
Effects on organs:
No macroscopic findings were observed at necropsy.
Other findings:
Signs of toxicity (local):
Test item residuals were noted in all animals from test day 2 until test day 6. Red-brown discoloration of the skin was observed in males and females from test day 2 until test day 14.

Applicant's summary and conclusion

Interpretation of results:
other: not classified within the CLP Regulation (EC 1272/2008)
Conclusions:
LD50 > 2000 mg/kg bw