Registration Dossier
Registration Dossier
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EC number: 700-713-3 | CAS number: 83161-22-2
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2004
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- GLP compliance:
- not specified
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- (2S,3R,4R,5R,6R)-2-methyl-6-(pentyloxy)oxane-3,4,5-triol
- EC Number:
- 700-713-3
- Cas Number:
- 83161-22-2
- Molecular formula:
- C11H22O5
- IUPAC Name:
- (2S,3R,4R,5R,6R)-2-methyl-6-(pentyloxy)oxane-3,4,5-triol
- Details on test material:
- For technical reason (solubility), APRC5 was diluted at 30% in a water/glycerol (1/5) mixture
This mixture corresponds to the industrial form.
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Study design: in vivo (non-LLNA)
- Positive control substance(s):
- yes
- Remarks:
- DNCB
Study design: in vivo (LLNA)
- Vehicle:
- other: water/glycerol mixture
- Concentration:
- Tested concentrations : 3, 15 and 30%
- No. of animals per dose:
- no data
- Positive control substance(s):
- other: DNCB
Results and discussion
In vivo (LLNA)
Results
- Parameter:
- other: disintegrations per minute (DPM)
- Remarks on result:
- other: See results table below
Any other information on results incl. tables
| 0 | 3% | 15% | 30% | |
| DPM-Blanc | 13814.5 | 9921.5 | 8328.5 | 6378.5 |
| DPM/Glanglion | 1726.8 | 1240.2 | 1041.1 | 797.3 |
| Ratio | - | 0.7 | 0.6 | 0.5 |
| Classification | - | no sensitisation | no sensitisation | no sensitisation |
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- APRC5 is not sensitising
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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