Registration Dossier

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed
Year:
1991

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: 84/449/EWG, 8.1
GLP compliance:
yes
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder
Details on test material:
- Name of test material (as cited in study report): 2-benzyl-2-dimethylamino-4'-morpholinobutyrophenone
- Molecular formula (if other than submission substance):C23H30N2O2
- Molecular weight (if other than submission substance):366.5
- Smiles notation (if other than submission substance):CCC(CC1=CC=CC=C1)(C(=O)C2=CC=C(C=C2)N3CCOCC3)N(C)C
- InChl (if other than submission substance):1S/C23H30N2O2/c1-4-23(24(2)3,18-19-8-6-5-7-9-19)22(26)20-10-12-21(13-11-20)25-14-16-27-17-15-25/h5-13H,4,14-18H2,1-3H3
- Physical state: Powder
- Analytical purity: >99%

Test animals

Species:
rat
Sex:
male/female

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 5 000
Remarks on result:
other: other information is unknown
Mortality:
Male: 2000 mglkg bw; Number of animals: 5; Number of deaths: 0
Male: 5000 mglkg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mglkg bw; Number of animals: 5; Number of deaths: 0
Female: 5000 mglkg bw; Number of animals: 5; Number of deaths: 0
Clinical signs:
Unspecific symptoms of intoxication, reversible within 10
days In all of the animals.
Gross pathology:
No findings

Applicant's summary and conclusion