Registration Dossier
Registration Dossier
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EC number: 939-509-6 | CAS number: -
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Reaction mass of 2,4 -Dichloronitrobenzene and 2,6 -Dichloronitrobenzene is a multiconstituent substance containing
(611 -06 -3) 2,4 -Dichloronitrobenzene : 50 -80 %
(601 -88 -7) 2,6.-Dichloronitrobenzene: 10 -50 %
(89 -61 -2) 2,5 -Dichloronitrobenzene 0 -5 %
(541 -73 -1) 1,3 Dichlorobenzene 0 -<1 %
mixture of 4,6 -dichloro-1,3 -dinitrobenzene and 2,4 -dichloro-1,3 -dinitrobenzene 0 -10 %
611 -06 -3
There are Ames teste, a HPRT-test and Chromosome aberration teste in vitro available leading to the overall result that this substance is a mutagen.
601 -88 -7
There are no data available
89 -61 -2
There are Ames tests and chomosome aberation tests available leading to the overall result that this substance is a mutagen.
541 -73 -1
There are different teste available examinating point mutations. chromosome aberrations and chromosome interaction .According to the German MAK-commission, 2007, on the basis of these data,.no final evaluation on mutagenic property can be given.
Mixture of 4,6 -dichloro-1,3 -dinitrobenzene and 2,4 -dichloro-1,3 -dinitrobenzene
There are no data available
OVERALL CONCLUSION
Based on the available information on mutagenic effects of the constituents of Reaction mass of 2,4 -Dichloronitrobenzene and 2,6 -Dichloronitr obenzene taking into account the main constituent 2,4 -Dichloronitrobenzene and the constituent 2,5 -Dichloronitrobenzene, it can be assumed that the Reaction mass of 2,4 -Dichloronitrobenzene and 2,6 -Dichloronitrobenzene has some mutagenic activity.
Short description of key information:
Based on the available information on mutagenic effects of the constituents of Reaction mass of 2,4 -Dichloronitrobenzene and 2,6 -Dichloronitr obenzene taking into account the main constituent 2,4 -Dichloronitrobenzene and the constituent 2,5 -Dichloronitrobenzene, it can be assumed that the Reaction mass of 2,4 -Dichloronitrobenzene and 2,6 -Dichloronitrobenzene has mutagenic activity.
Endpoint Conclusion:
Justification for classification or non-classification
Based on the available information given by numourous tests the Reaction mass of 2,4 -Dichloronitrobenzene and 2,6 -Dichloronitr obenzene has to be allocated to category Mut 2 according to Regulation (EC) 1272, 2008 (GHS). according to Regulation (EC) 67/548/EWG Reaction mass of 2,4 -Dichloronitrobenzene and 2,6 -Dichloronitrobenzene has to be classified/labelled with R68 = possible risk of irreversible effects.
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