Registration Dossier
Registration Dossier
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EC number: 221-255-6 | CAS number: 3047-33-4
Carcinogenicity
Administrative data
Description of key information
Read-across from 2 year carcinogenicity studies in rats and mice (monosodium salt and monosodium monohydrate salt of cyanuric acid were non-oncogenic by the oral route). Trisodium cyanurate is also considered non-oncogenic at the same conditions.
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 176.5 mg/kg bw/day
Justification for classification or non-classification
In both studies, under the experimental conditions, there is no evidence of carcinogenic potential of the test material
Additional information
Read-across:
1. Based on the experimental results obtained with the analogue monosodium salt of cyanuric acid, monohydrate (NOAEL ca. 154 mg/kg bw/day, male and NOAEL ca. 266 mg/kg bw/day, female) and the molecular weights, the read-across approach is applied and the NOAEL for substance trisodium cyanurate is calculated to be 176.5 mg/kg bw/day
(male) and 304.9 mg/kg bw/day (female).
2. Based on the experimental results obtained with the analogue monosodium salt of cyanuric acid (NOAEL ca. 1520 mg/kg bw/day, male and NOAEL ca. 1580 mg/kg bw/day, female) and the molecular weights, the read-across approach is applied and the NOAEL for substance trisodium cyanurate are calculated to be ca. 1948.9 mg/kg bw/day, male and 2025.8 mg/kg bw/day, female.
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