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Diss Factsheets
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EC number: 219-323-5 | CAS number: 2414-98-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study based on national / international standards
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: US Fed. Reg. 38, No. 187, § 1500.41 (skin) P. 27019 of 27 Sep. 1973.
- GLP compliance:
- no
- Remarks:
- not yet stipulated at that time
Test material
- Reference substance name:
- Magnesium ethanolate
- EC Number:
- 219-323-5
- EC Name:
- Magnesium ethanolate
- Cas Number:
- 2414-98-4
- Molecular formula:
- C2H6O.1/2Mg
- IUPAC Name:
- magnesium ethanolate
- Details on test material:
- - Name of test material (as cited in study report): Magnesium ethylate
- Molecular formula (if other than submission substance): Mg(OC2H5)2
- Molecular weight (if other than submission substance): 114.43
- Substance type: organometallic
- Physical state: solid
- Analytical purity: no data
- Lot/batch No.: no data
- Stability under test conditions: not stable
- Storage condition of test material: Sensitive to hydrolysis and air
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: no data
- Weight at study initiation: 3 - 4 kg
- Housing: stainless-steel cage without litter, 1 animal per cage
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: > 3 d
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +-1
- Humidity (%): 55 +-10
- air-conditioned
- Photoperiod (hrs dark / hrs light): 12 / 12
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: shaved: intact and abraded site
- Vehicle:
- other: peanut oil
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 g
- Concentration (if solution): 50 % in anhydrous peanut oil
VEHICLE
- Amount(s) applied (volume or weight with unit): 1 g
- Concentration (if solution): 50 % pasty suspension - Duration of treatment / exposure:
- 24 h
- Observation period:
- 7 d
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: approx. 2.5 cm x 2.5 cm = approx. 6.25 cm2
- Type of wrap if used: Gauze is fastened with an elastic bandage, on top PVC film fixed with adhesive plaster
REMOVAL OF TEST SUBSTANCE
- Washing (if done): on data
SCORING SYSTEM: according to Draize, J.H. (1959) DERMAL TOXICITY
Results and discussion
In vivo
Results
- Irritation parameter:
- primary dermal irritation index (PDII)
- Remarks:
- based on Draize Scoring System
- Basis:
- mean
- Remarks:
- of 6 animals
- Time point:
- other: 24 + 72 h
- Score:
- 0.46
- Max. score:
- 8
- Irritant / corrosive response data:
- Very slight edema (score 1) have been reported on the intact skin of 2/6 animals after 72 h;
Very slight and slight edema (score 1 and 2) have been reported on the scarified skin of 5/6 and 1/6 animals, respectively, after 72 h.
No edemas were noted (score 0). - Other effects:
- In 3 rabbits, brownish colorations were found in the scarified skin area.
The subcutaneous connective tissue and the muscles underneath were unremarkable.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- Magnesium ethanolate can be considered as non-irritating to the skin.
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