Registration Dossier
Registration Dossier
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EC number: 202-810-1 | CAS number: 100-01-6
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from an authoritative source and the process of obtaining the reprint that shall give legitimate access to the study is on-going.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- NIOSH/OSHA - Occupational Health Guidelines for Chemical Hazards
- Author:
- Mackison, F. W., R. S. Stricoff, and L. J. Partridge, Jr. (eds.)
- Year:
- 1 981
- Bibliographic source:
- DHHS(NIOSH) Publication No. 81-123 (3 VOLS). Washington, DC: U.S. Government Printing Office, Jan. 1981., p. 2
- Reference Type:
- other: Authoritative data base
- Title:
- GCID: 48
- Year:
- 2 011
- Bibliographic source:
- Aggregated Computational Toxicology Resource (ACToR)
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- data obtained from Actor database
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-nitroaniline
- EC Number:
- 202-810-1
- EC Name:
- 4-nitroaniline
- Cas Number:
- 100-01-6
- Molecular formula:
- C6H6N2O2
- IUPAC Name:
- 4-nitroaniline
- Details on test material:
- - Name of test material (as cited in study report): 4-nitroaniline
- Substance type: Organic
- Physical state: solid
Constituent 1
Test animals / tissue source
- Species:
- other: no data
Test system
- Vehicle:
- not specified
- Controls:
- not specified
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks on result:
- other: Is mildly irritating to the eyes and may cause some corneal damage.
Applicant's summary and conclusion
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- 4-nitroaniline is mildly irritating to the eyes and may cause some corneal damage. However, the slightly irritating effect to the eye is not considered substantial enough to classify 4-nitroaniline as an eye irritant.
- Executive summary:
4-nitroaniline is mildly irritating to the eyes and may cause some corneal damage. However, the slightly irritating effect to the eye is not considered substantial enough to classify 4-nitroaniline as an eye irritant.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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